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Rabbit anti-Human, Mouse OTUD4 Polyclonal Antibody | anti-OTUD4 antibody

OTUD4 Antibody

Gene Names
OTUD4; HIN1; DUBA6; HSHIN1
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
OTUD4; Polyclonal Antibody; OTUD4 Antibody; DKFZp434I0721; DUBA6; HIN1; HIV 1 induced protein HIN 1; HIV 1 INTEGRATION 1; HIV-1-induced protein HIN-1; HSHIN; HSHIN1; KIAA1046; OTU domain containing 4; OTU domain containing 4 protein; OTU domain-containing protein 4; OTUD4_HUMAN; anti-OTUD4 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
OTUD4 Antibody detects endogenous levels of OTUD4.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-OTUD4 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human OTUD4.
Conjugation
Unconjugated
Post Translational Modifications
Phosphorylated on Ser-202 and Ser-204 likely by CSNK2A1-CSNK2A2 serine/threonine-protein kinase complex. Activates 'Lys-63'-specific deubiquitinase activity.
Subunit Structure
Interacts with MYD88; the interaction is direct. Interacts with ALKBH3; the interaction is direct. Interacts with USP7; the interaction is direct. Interacts with USP9X; the interaction is direct.
Function
Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions.
Note
Primarily cytoplasmic.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-OTUD4 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
17,036 Da
NCBI Official Full Name
OTU domain-containing protein 4 isoform 3
NCBI Official Synonym Full Names
OTU deubiquitinase 4
NCBI Official Symbol
OTUD4
NCBI Official Synonym Symbols
HIN1; DUBA6; HSHIN1
NCBI Protein Information
OTU domain-containing protein 4; OTU domain containing 4; HIV-1 induced protein HIN-1; HIV-1-induced protein HIN-1
UniProt Protein Name
OTU domain-containing protein 4
UniProt Gene Name
OTUD4
UniProt Synonym Gene Names
HIN1; KIAA1046
UniProt Entry Name
OTUD4_HUMAN

NCBI Description

Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010]

Uniprot Description

OTUD4: Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010]

Protein type: Hydrolase; EC 3.4.19.12

Chromosomal Location of Human Ortholog: 4q31.21

Molecular Function: ubiquitin-specific protease activity

Biological Process: proteolysis

Research Articles on OTUD4

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Product Notes

The OTUD4 otud4 (Catalog #AAA9630259) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The OTUD4 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's OTUD4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the OTUD4 otud4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OTUD4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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