Rabbit anti-Human OSCAR Polyclonal Antibody | anti-OSCAR antibody

OSCAR, CT (OSCAR, Osteoclast-associated immunoglobulin-like receptor, Polymeric immunoglobulin receptor 3) (Biotin)

Cat. Num. AAA6329726

• Gene Names: OSCAR; PIGR3; PIgR-3
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: OSCAR; Polyclonal Antibody; CT (OSCAR; Osteoclast-associated immunoglobulin-like receptor; Polymeric immunoglobulin receptor 3) (Biotin); Polymeric immunoglobulin receptor 3; anti-OSCAR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-OSCAR antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: OSCAR antibody is generated from rabbits immunized with a KLH conjugated synthetic between 204-231 amino acids selected from the C-terminal region of human OSCAR.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(OSCAR Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the OSCAR antibody detected the OSCAR protein (arrow).)

Related Product Information for anti-OSCAR antibody

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-OSCAR antibody

Antibodies; Receptors

References

Davila, S., et al. Genes Immun. 11(3):232-238(2010). Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009). Herman, S., et al. Arthritis Rheum. 58(10):3041-3050(2008). Merck, E., et al. J. Immunol. 176(5):3149-3156(2006). Kim, K., et al. J. Biol. Chem. 280(42):35209-35216(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 45580713
• NCBI GeneID: 126014
• NCBI Accession #: NP_570127.2
• NCBI GenBank Nucleotide #: NM_130771.3
• UniProt Accession #: Q8IYS5; Q5GRG5; Q8N763; Q8NHL4; Q8WXQ0; Q8WXQ1; Q8WXQ2; B7WNS2
• Molecular Weight: 30,481 Da
• NCBI Official Full Name: osteoclast-associated immunoglobulin-like receptor isoform 3
• NCBI Official Synonym Full Names: osteoclast associated, immunoglobulin-like receptor
• NCBI Official Symbol: OSCAR
• NCBI Official Synonym Symbols: PIGR3; PIgR-3
• NCBI Protein Information: osteoclast-associated immunoglobulin-like receptor; poly-Ig receptor 3; polymeric immunoglobulin receptor 3; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2
• UniProt Protein Name: Osteoclast-associated immunoglobulin-like receptor
• Protein Family: Osteoclast-associated immunoglobulin-like receptor
• UniProt Gene Name: OSCAR
• UniProt Synonym Gene Names: Osteoclast-associated receptor; hOSCAR; PIgR-3; PIgR3
• UniProt Entry Name: OSCAR_HUMAN

NCBI Description

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Uniprot Description

OSCAR: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: plasma membrane; integral to membrane