Rabbit anti-Human, Mouse OSBPL5 Polyclonal Antibody | anti-OSBPL5 antibody

OSBPL5 Antibody

Cat. Num. AAA9629594

• Gene Names: OSBPL5; ORP5; OBPH1
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: OSBPL5; Polyclonal Antibody; OSBPL5 Antibody; DKFZp586H1719; FLJ31948; KIAA1534; OBPH1; ORP 5; ORP5; OSBP related protein 5; Oxysterol binding protein homolog 1; Oxysterol binding protein homologue 1; Oxysterol binding protein like 5; Oxysterol binding protein related protein 5; anti-OSBPL5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: OSBPL5 Antibody detects endogenous levels of total OSBPL5.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-OSBPL5 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: Belongs to the OSBP family.
• Tissue Specificity: Ubiquitously expressed.
• Function: Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholesterol.
• Note: Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Localizes to the cortical endoplasmic reticulum at the EPCS.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-OSBPL5 antibody

Endoplasmic reticulum membrane; Single-pass membrane protein; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 14149740
• NCBI GeneID: 114879
• NCBI Accession #: NP_065947.1
• NCBI GenBank Nucleotide #: NM_020896.3
• UniProt Accession #: Q9H0X9; Q54A90; Q8N596; Q9BZB0; Q9P1Z4; A6NDP0; A6NJS8; B4DVB0
• Molecular Weight: 90,794 Da
• NCBI Official Full Name: oxysterol-binding protein-related protein 5 isoform a
• NCBI Official Synonym Full Names: oxysterol binding protein like 5
• NCBI Official Symbol: OSBPL5
• NCBI Official Synonym Symbols: ORP5; OBPH1
• NCBI Protein Information: oxysterol-binding protein-related protein 5
• UniProt Protein Name: Oxysterol-binding protein-related protein 5
• Protein Family: Oxysterol-binding protein-related protein
• UniProt Gene Name: OSBPL5
• UniProt Synonym Gene Names: KIAA1534; OBPH11 PublicationManual assertion based on opinion iniRef.1; ORP-5; OSBP-related protein 5

NCBI Description

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

Uniprot Description

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).