Rabbit anti-Human OSBPL5 Polyclonal Antibody | anti-OSBPL5 antibody

OSBPL5 Rabbit pAb

Cat. Num. AAA9143169

• Gene Names: OSBPL5; ORP5; OBPH1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity purification
• Synonyms: OSBPL5; Polyclonal Antibody; OSBPL5 Rabbit pAb; ORP5; OBPH1; anti-OSBPL5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Applicable Applications for anti-OSBPL5 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human OSBPL5.
• Positive Samples: HeLa, LO2
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using OSBPL5 antibody at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (RM00020).Exposure time: 90s.)

Related Product Information for anti-OSBPL5 antibody

Background: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified.

Product Categories/Family for anti-OSBPL5 antibody

Endocrine & Metabolism; Lipid Metabolism; Cholesterol Metabolism

NCBI and Uniprot Product Information

• NCBI GI #: 14149740
• NCBI GeneID: 114879
• NCBI Accession #: NP_065947.1
• NCBI GenBank Nucleotide #: NM_020896.3
• UniProt Accession #: Q9H0X9; Q54A90; Q8N596; Q9BZB0; Q9P1Z4; A6NDP0; A6NJS8; B4DVB0
• Molecular Weight: 90,794 Da
• NCBI Official Full Name: oxysterol-binding protein-related protein 5 isoform a
• NCBI Official Synonym Full Names: oxysterol binding protein like 5
• NCBI Official Symbol: OSBPL5
• NCBI Official Synonym Symbols: ORP5; OBPH1
• NCBI Protein Information: oxysterol-binding protein-related protein 5
• UniProt Protein Name: Oxysterol-binding protein-related protein 5
• Protein Family: Oxysterol-binding protein-related protein
• UniProt Gene Name: OSBPL5
• UniProt Synonym Gene Names: KIAA1534; OBPH11 PublicationManual assertion based on opinion iniRef.1; ORP-5; OSBP-related protein 5

NCBI Description

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

Uniprot Description

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).