Western Blot (WB)
(Anti-OPCML antibody, MBS175644, Western blottingWB: Rat Brain Tissue Lysate )
Rabbit OPCML Polyclonal Antibody | anti-OPCML antibody
Anti-OPCML antibody
Western Blot (WB)
(Anti-OPCML antibody, MBS175644, Western blottingWB: Rat Brain Tissue Lysate )
Western Blot (WB)
(Anti-OPCML antibody, MBS175644, Western blottingWB: Rat Brain Tissue Lysate )
Immunohistochemistry (IHC)
(Anti-OPCML antibody, MBS175644, IHC(P)IHC(P): Human Mammary Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-OPCML antibody, MBS175644, IHC(P)IHC(P): Human Mammary Cancer Tissue )
Background: Opioid-binding protein/cell adhesion molecule-like(OPCML),(also called opioid-binding cell adhesion molecule(OBCAM). OPCML is a member of the IgLON family of immunoglobulin(Ig) domain-containing glycosylphosphatidylinositol(GPI)-anchored cell adhesion molecules, as an excellent candidate for the 11q25 ovarian cancer TSG in EOC. The OPCML gene comprises 7 exons, spans approximately 600 kb, and is transcribed from telomere to centromere. And due to the lack of transmembrane domains necessary for signal transduction, it is improbable that OBCAM acts independently as an opioid receptor; more likely, it plays an important accessory role in opioid receptor function.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
OPCML: Binds opioids in the presence of acidic lipids; probably involved in cell contact. Defects in OPCML are a cause of susceptibility to ovarian cancer (OC). Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late- stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Belongs to the immunoglobulin superfamily. IgLON family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 11q25
Cellular Component: neuron projection; cell surface; cell soma; plasma membrane; intercellular junction
Biological Process: cell-cell adhesion; regulation of neurogenesis; neuron recognition; cell adhesion
Disease: Ovarian Cancer
Research Articles on OPCML
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Product Notes
The OPCML opcml (Catalog #AAA175644) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-OPCML antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's OPCML can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the OPCML opcml for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OPCML, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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