Rabbit OPCml Polyclonal Antibody | anti-OPCml antibody

OPCml Antibody

Cat. Num. AAA5312606

• Gene Names: OPCML; OPCM; OBCAM; IGLON1
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Chromatography
• Synonyms: OPCml; Polyclonal Antibody; OPCml Antibody; Affinity Purified Rabbit Polyclonal OPCml Antibody; Polyclonal OPCml antibody; Anti-OPCml antibody; OBCAM antibody; Opioid binding cell adhesion molecule antibody; Opioid-binding protein cell adhesion molecule-like antibody; anti-OPCml antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Chromatography
• Form/Format: Lyophilized Form
• Sequence Length: 338

• Applicable Applications for anti-OPCml antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin
• Immunogen: OPCml antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human OPCML, identical to the related rat and Rabbit sequence as the immunogen
• Preparation and Storage: Store at 4 degree C for short term storage. For long term storage aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded section of Human Mammary Cancer Tissue)

Western Blot (WB)

(Western Blot using Rat Brain Tissue Lysate)

Related Product Information for anti-OPCml antibody

OPCml is a member of the IgLON family of immunoglobulin (Ig)domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules, as an excellent candidate for the 11q25 ovarian cancer TSG in EOC. The OPCml gene comprises 7 exons, spans approximately 600 kb, and is transcribed from telomere to centromere. And due to the lack of transmembrane domains necessary for signal transduction, it is improbable that OBCAM acts independently as an opioid receptor; more likely, it plays an important accessory role in opioid receptor function.

Product Categories/Family for anti-OPCml antibody

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 59939900
• NCBI GeneID: 4978
• NCBI GenBank Nucleotide #: NP_001012393.1
• UniProt Accession #: Q14982
• NCBI Official Full Name: opioid-binding protein/cell adhesion molecule isoform b
• NCBI Official Synonym Full Names: opioid binding protein/cell adhesion molecule like
• NCBI Official Symbol: OPCML
• NCBI Official Synonym Symbols: OPCM; OBCAM; IGLON1
• NCBI Protein Information: opioid-binding protein/cell adhesion molecule
• UniProt Protein Name: Opioid-binding protein/cell adhesion molecule
• Protein Family: Opioid-binding protein/cell adhesion molecule
• UniProt Gene Name: OPCML
• UniProt Synonym Gene Names: IGLON1; OBCAM; OBCAM; OPCML; Opioid-binding cell adhesion molecule
• UniProt Entry Name: OPCM_HUMAN

NCBI Description

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Description

OPCML: Binds opioids in the presence of acidic lipids; probably involved in cell contact. Defects in OPCML are a cause of susceptibility to ovarian cancer (OC). Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late- stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Belongs to the immunoglobulin superfamily. IgLON family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11q25

Cellular Component: neuron projection; cell surface; cell soma; plasma membrane; intercellular junction

Biological Process: cell-cell adhesion; regulation of neurogenesis; neuron recognition; cell adhesion

Disease: Ovarian Cancer