Rabbit anti-Human OAS3 Polyclonal Antibody | anti-Oas3 antibody

OAS3, CT (2'-5'-oligoadenylate Synthase 3, (2-5')oligo(A) Synthase 3, 2-5A Synthase 3, p100 OAS, p100OAS, P/OKcl.4)

Cat. Num. AAA626368

• Gene Names: Oas3; Oasl10
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: OAS3; Polyclonal Antibody; CT (2'-5'-oligoadenylate Synthase 3; (2-5')oligo(A) Synthase 3; 2-5A Synthase 3; p100 OAS; p100OAS; P/OKcl.4); Anti -OAS3; anti-Oas3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human OAS3.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-Oas3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:1,000; Western Blot: 1:100-1:500
• Immunogen: Synthetic peptide selected from the C-terminal region of human OAS3 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(The anti-OAS3 C-term Antibody is used in Western blot to detect OAS3 in A375 lysate.)

Related Product Information for anti-Oas3 antibody

OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.

Product Categories/Family for anti-Oas3 antibody

Antibodies; Abs to Enzymes; Synthase

NCBI and Uniprot Product Information

• NCBI GI #: 16741244
• NCBI GeneID: 246727
• UniProt Accession #: Q91YM7; Q14BH3; Q8K4D2; Q8VI93
• Molecular Weight: 57,700 Da
• NCBI Official Full Name: Oas3 protein
• NCBI Official Synonym Full Names: 2'-5' oligoadenylate synthetase 3
• NCBI Official Symbol: Oas3
• NCBI Official Synonym Symbols: Oasl10
• NCBI Protein Information: 2'-5'-oligoadenylate synthase 3; 2'-5' oligoadenylate synthetase-like 10
• UniProt Protein Name: Oas3 protein
• Protein Family: 2'-5'-oligoadenylate synthase
• UniProt Gene Name: Oas3
• UniProt Entry Name: Q91YM7_MOUSE

Uniprot Description

OAS3: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). Belongs to the 2-5A synthase family.

Protein type: EC 2.7.7.84; Transferase

Cellular Component: nucleoplasm; extracellular space; cytoplasm; plasma membrane; nucleus

Molecular Function: transferase activity; RNA binding; metal ion binding; double-stranded RNA binding; nucleotide binding; ATP binding; nucleotidyltransferase activity; 2'-5'-oligoadenylate synthetase activity

Biological Process: negative regulation of viral genome replication; immune system process; response to virus; innate immune response; immune response; defense response to virus