Western Blot (WB)
(NUMBL Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the NUMBL antibody detected the NUMBL protein (arrow).)
Rabbit anti-Human NUMBL Polyclonal Antibody | anti-NUMBL antibody
NUMBL Antibody (C-term)
Western Blot (WB)
(NUMBL Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the NUMBL antibody detected the NUMBL protein (arrow).)
Western Blot (WB)
(NUMBL Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the NUMBL antibody detected the NUMBL protein (arrow).)
Immunohistochemistry (IHC)
(NUMBL Antibody (C-term) (MBS9204395)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NUMBL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(NUMBL Antibody (C-term) (MBS9204395)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NUMBL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Blom, T., et al. Cancer Genet. Cytogenet. 186(2):103-109(2008)
Ma, Q., et al. Cell. Signal. 20(6):1044-1051(2008)
Passos Gregorio, S., et al. Schizophr. Res. 88 (1-3), 275-282 (2006) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
NCBI and Uniprot Product Information
Uniprot Description
NUMBL: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. Interacts (via PTB domain) with MAP3K7IP2 (via C- terminal). Interacts (via C-terminal) with TRAF6 (via TRAF domains). Associates with EPS15 and NOTCH1.
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: 19q13.13-q13.2
Cellular Component: cytoplasm
Molecular Function: protein binding
Biological Process: nervous system development; positive regulation of neurogenesis; axonogenesis; cytokine and chemokine mediated signaling pathway; protein metabolic process; neuroblast division in the subventricular zone; positive regulation of dendrite morphogenesis; lateral ventricle development
Research Articles on NUMBL
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Product Notes
The NUMBL numbl (Catalog #AAA9204395) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 572-600. The NUMBL Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NUMBL can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the NUMBL numbl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NUMBL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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