Western Blot (WB)
(Western blotAll lanes: NRG2 antibody at 16ug/ml+ U251 whole cell lysateGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 92,91,93,47,46,68,71 kDaObserved band size: 92 kDa)
Rabbit anti-Human NRG2 Polyclonal Antibody | anti-NRG2 antibody
NRG2 Antibody
Western Blot (WB)
(Western blotAll lanes: NRG2 antibody at 16ug/ml+ U251 whole cell lysateGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 92,91,93,47,46,68,71 kDaObserved band size: 92 kDa)
Western Blot (WB)
(Western blotAll lanes: NRG2 antibody at 16ug/ml+ U251 whole cell lysateGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 92,91,93,47,46,68,71 kDaObserved band size: 92 kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lung cancer using MBS7002560 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lung cancer using MBS7002560 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunofluorescent analysis of PC3 cells using MBS7002560 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Immunohistochemistry (IHC)
(Immunofluorescent analysis of PC3 cells using MBS7002560 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]
Uniprot Description
NRG2: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. Belongs to the neuregulin family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: extracellular region; extracellular space; integral to membrane; intracellular; plasma membrane
Molecular Function: growth factor activity; receptor binding
Biological Process: activation of MAPKK activity; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; organ development; phosphoinositide-mediated signaling; Ras protein signal transduction; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
Research Articles on NRG2
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Product Notes
The NRG2 nrg2 (Catalog #AAA7002560) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NRG2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NRG2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Recommended dilution: WB:1:500-2000, IHC:1:20-1:200. Researchers should empirically determine the suitability of the NRG2 nrg2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NRG2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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