Immunohistochemistry (IHC)
(Immunochemical staining of human NR1H2 in human testis with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human NR1H2/LXR beta Polyclonal Antibody | anti-NR1H2 antibody
Anti-NR1H2/LXR beta Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
NR1H2/LXR beta; Polyclonal Antibody; Anti-NR1H2/LXR beta Antibody; Rabbit Polyclonal; NR1H2/LXR beta Antibody; Rabbit PAb; Antigen Affinity Purified; nuclear receptor subfamily 1; group H; member 2; Anti-LXR-b Antibody; Anti-LXRB Antibody; Anti-NER Antibody; Anti-NER-I Antibody; Anti-RIP15 Antibody; Anti-UNR Antibody; anti-NR1H2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human NR1H2/LXR beta
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-NR1H2 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human NR1H2/LXR beta fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human NR1H2/LXR beta fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human NR1H2 in human testis with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human NR1H2 in human testis with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-NR1H2 antibody
NR1H2 (Nuclear Receptor Subfamily 1 Group H Member 2) is a Protein Coding gene. Liver X receptor Beta (LXRbeta), located in an obesity susceptible region, is involved in the metabolism of lipid and carbohydrates. Previous human genetic studies have suggested genetic variability of LXRbeta could be associated with human obesity. Diseases associated with NR1H2 include Complete Androgen Insensitivity Syndrome and Biliary Tract Disease. Among its related pathways are Lipoprotein metabolism and Sterol Regulatory Element-Binding Proteins (SREBP) signaling. LXRbeta is a promising therapeutic target for lipid disorders, atherosclerosis, chronic inflammation, autoimmunity, cancer, and neurodegenerative diseases. Discovery and optimization of selective liver X receptor beta (LXRbeta) agonists are challenging due to the high homology of LXRalpha and LXRbeta in the ligand-binding domain
References
Mehrad-Majd H, et al. (2018) Genetic association of liver x receptor beta rs2695121 polymorphism with obesity-related traits in a northeastern iranian population. Electron Physician 10 (1): 6249-6254.Luo GG, et al. (2016) [discovery of potential lxrbeta agonists from chinese herbs using molecular simulation methods]. Zhongguo Zhong Yao Za Zhi 41 (16): 3065-3071.Chen H, et al. (2020) Discovery of new lxrbeta agonists as glioblastoma inhibitors. Eur J Med Chem 194 112240.
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Product Notes
The NR1H2 (Catalog #AAA8109094) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-NR1H2/LXR beta Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NR1H2/LXR beta can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the NR1H2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NR1H2/LXR beta, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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