Rabbit NPY Polyclonal Antibody | anti-NPY antibody

NPY antibody

Cat. Num. AAA9413962

• Gene Names: NPY; PYY4
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: NPY; Polyclonal Antibody; NPY antibody; PYY4; Neuropeptide Y CPON; anti-NPY antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total NPY antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 97

• Applicable Applications for anti-NPY antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500 - 1:2000
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human NPY.
• Target Name: NPY
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of 293T cell lines, using NPY antibody.)

Related Product Information for anti-NPY antibody

The NPY hormone family consists of NPY, PP and peptide YY. NPY (neuropeptide Y) is a 36 amino acid protein that consists of a polyproline stretch followed by an amphipathic a-helix. NPY shares a 50% amino acid homology with pancreatic polypeptide gene (PP). NPY is expressed throughout the central and peripheral nervous system, particularly in the deep layers of the cortex and smaller cell bodies in the white matter. NPY interacts with the Y-receptor family of G protein-coupled receptors. NPY interacts with NPY receptor Y1 to increase corticotropin levels and decrease noradrenaline levels in the hypothalamus. Through interactions in the hypothalus, NPY plays important roles in the regulation of energy balance by stimulating food intake. NPY favors energy storage by increasing lipoprotein lipase activity in white adipose tissue. A Leucine 7 to Proline 7 polymorphism has been implicated in an increase in alcohol preference, and decrease in cholesterol metabolism.

Product Categories/Family for anti-NPY antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4505449
• NCBI GeneID: 4852
• NCBI Accession #: NP_000896.1
• NCBI GenBank Nucleotide #: NM_000905.3
• UniProt Accession #: P01303
• Molecular Weight: 10,851 Da
• NCBI Official Full Name: pro-neuropeptide Y preproprotein
• NCBI Official Synonym Full Names: neuropeptide Y
• NCBI Official Symbol: NPY
• NCBI Official Synonym Symbols: PYY4
• NCBI Protein Information: pro-neuropeptide Y
• UniProt Protein Name: Pro-neuropeptide Y
• Protein Family: Neuropeptide
• UniProt Gene Name: NPY
• UniProt Synonym Gene Names: NPY; CPON
• UniProt Entry Name: NPY_HUMAN

NCBI Description

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

Uniprot Description

NPY: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Belongs to the NPY family.

Protein type: Secreted; Hormone; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p15.1

Cellular Component: Golgi apparatus; extracellular space; cell; extracellular region

Molecular Function: G-protein coupled receptor activity; neuropeptide hormone activity; neuropeptide Y receptor binding; calcium channel regulator activity; receptor binding

Biological Process: blood circulation; behavior; adult feeding behavior; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; cell proliferation; neuropeptide signaling pathway; calcium ion transport; positive regulation of appetite; regulation of blood pressure; regulation of appetite; digestion; feeding behavior; cerebral cortex development; cell motility; neurite development; central nervous system neuron development