Testing Data
(Sample (30 ug of whole cell lysate)A: Hep G2 7.5% SDS PAGEPrimary antibody diluted at 1: 10000)
Rabbit anti-Human NPR-C Polyclonal Antibody | anti-NPR-C antibody
NPR-C antibody
Immunohistochemistry: 1:100-1:500
Immunofluorescence: 1:100-1:200
Testing Data
(Sample (30 ug of whole cell lysate)A: Hep G2 7.5% SDS PAGEPrimary antibody diluted at 1: 10000)
Testing Data
(Sample (30 ug of whole cell lysate)A: Hep G2 7.5% SDS PAGEPrimary antibody diluted at 1: 10000)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded U87 xenograft, using NPR-C antibody at 1: 500 dilution.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded U87 xenograft, using NPR-C antibody at 1: 500 dilution.)
Immunofluorescence (IF)
(Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using NPR-C antibody at 1: 200 dilution.)
Immunofluorescence (IF)
(Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using NPR-C antibody at 1: 200 dilution.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Uniprot Description
ANP-C: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. Belongs to the ANF receptor family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5p13.3
Cellular Component: integral to plasma membrane; intracellular; plasma membrane
Molecular Function: adenylate cyclase activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled; protein homodimerization activity
Biological Process: cAMP biosynthetic process; cAMP-mediated signaling; cyclic nucleotide biosynthetic process; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); negative regulation of adenylate cyclase activity; negative regulation of smooth muscle cell proliferation; pancreatic juice secretion; phosphoinositide-mediated signaling; positive regulation of nitric-oxide synthase activity; regulation of blood pressure; regulation of osteoblast proliferation; skeletal development
Research Articles on NPR-C
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Product Notes
The NPR-C npr3 (Catalog #AAA9406140) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NPR-C antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NPR-C can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). Western blotting: 1:500-1:3000 Immunohistochemistry: 1:100-1:500 Immunofluorescence: 1:100-1:200. Researchers should empirically determine the suitability of the NPR-C npr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NPR-C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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