Western Blot (WB)
(NPPC Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the NPPC antibody detected the NPPC protein (arrow).)
Rabbit anti-Human NPPC Polyclonal Antibody | anti-NPPC antibody
NPPC Antibody (C-term)
Western Blot (WB)
(NPPC Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the NPPC antibody detected the NPPC protein (arrow).)
Western Blot (WB)
(NPPC Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the NPPC antibody detected the NPPC protein (arrow).)
Immunohistochemistry (IHC)
(NPPC Antibody (C-term) (MBS9203387)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NPPC Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(NPPC Antibody (C-term) (MBS9203387)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NPPC Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
related molecules: atrial natriuretic peptide (ANP; MIM 108780),
brain natriuretic peptide (BNP; MIM 600295), and C-type natriuretic
peptide, CNP, encoded by a gene symbolized NPPC. These peptides
possess potent natriuretic, diuretic, and vasodilating activities
and are implicated in body fluid homeostasis and blood pressure
control.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Wang, Y., et al. J. Cardiovasc. Pharmacol. 55(1):62-66(2010)
Cammarata, P.R., et al. Mol. Vis. 16, 630-638 (2010) :
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is proteolytically processed to form a secreted hormone of the natriuretic peptide family. The encoded hormone regulates the growth and differentiation of cartilaginous growth plate chondrocytes and may also be vasoactive and natriuretic. [provided by RefSeq, Sep 2011]
Uniprot Description
NPPC: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.
Protein type: Hormone; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: extracellular space; secretory granule
Molecular Function: protein homodimerization activity; peptide hormone receptor binding; hormone activity; receptor binding
Biological Process: response to drug; cGMP biosynthetic process; ossification; regulation of smooth muscle cell proliferation; regulation of cAMP metabolic process; regulation of multicellular organism growth; negative regulation of meiotic cell cycle; positive regulation of vasodilation; negative regulation of DNA metabolic process; post-embryonic development; positive regulation of osteoblast differentiation; negative regulation of cell proliferation; response to ethanol; positive regulation of cGMP biosynthetic process; receptor guanylyl cyclase signaling pathway; response to hypoxia; regulation of cGMP metabolic process; regulation of blood vessel size
Research Articles on NPPC
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Product Notes
The NPPC nppc (Catalog #AAA9203387) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 80-109. The NPPC Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NPPC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the NPPC nppc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NPPC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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