Rabbit NPBWR2 / GPR8 Polyclonal Antibody | anti-NPBWR2 antibody

Rabbit Polyclonal to Human NPBWR2 / GPR8

Cat. Num. AAA242814

• Gene Names: NPBWR2; GPR8
• Reactivity: Gorilla, Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: NPBWR2 / GPR8; Polyclonal Antibody; Rabbit Polyclonal to Human NPBWR2 / GPR8; Anti-NPBWR2 / GPR8 Antibody (N-Terminus) IHC-plus; NPBWR2; G protein-coupled receptor 8; G-protein coupled receptor 8; GPR8; Neuropeptides B/W receptor 2; Human NPBWR2; anti-NPBWR2 antibody

• Host: Rabbit
• Reactivity: Gorilla, Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human NPBWR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ADAM19 (59%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 333

• Applicable Applications for anti-NPBWR2 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (3 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 17 amino acid peptide from N-terminal extracellular domain of human NPBWR2. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Marmoset (94%); Gibbon (88%).
• Immunogen Type: Synthetic peptide
• Immunogen: NPBWR2 / GPR8 antibody was raised against synthetic 17 amino acid peptide from N-terminal extracellular domain of human NPBWR2. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Marmoset (94%); Gibbon (88%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-NPBWR2 / GPR8 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-NPBWR2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-NPBWR2 / GPR8 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-NPBWR2 antibody

GPR8 is a Neuropeptide Receptor GPCR. GPR8 is implicated in the regulation of feeding and prolactin release by binding to NPW.

Product Categories/Family for anti-NPBWR2 antibody

Family: GPCR; Subfamily: Neuropeptide

NCBI and Uniprot Product Information

• NCBI GI #: 30581164
• NCBI GeneID: 2832
• NCBI Accession #: NP_005277.2
• NCBI GenBank Nucleotide #: NM_005286.2
• UniProt Accession #: P48146; Q6NWQ6; Q9H4K3
• Molecular Weight: 36,861 Da
• NCBI Official Full Name: neuropeptides B/W receptor type 2
• NCBI Official Synonym Full Names: neuropeptides B/W receptor 2
• NCBI Official Symbol: NPBWR2
• NCBI Official Synonym Symbols: GPR8
• NCBI Protein Information: neuropeptides B/W receptor type 2; G protein-coupled receptor 8; G-protein coupled receptor 8; opioid-somatostatin-like receptor 8
• UniProt Protein Name: Neuropeptides B/W receptor type 2
• Protein Family: Neuropeptides B/W receptor
• UniProt Gene Name: NPBWR2
• UniProt Synonym Gene Names: GPR8
• UniProt Entry Name: NPBW2_HUMAN

NCBI Description

The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008]

Uniprot Description

NPBWR2: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: neuron projection; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: neuropeptide binding; protein binding; neuropeptide receptor activity; opioid receptor activity

Biological Process: synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway