Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) Polyclonal Antibody | anti-NME1 antibody
Polyclonal Antibody to Non Metastatic Cells 1, Protein NM23A Expressed In (NME1)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-RTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF LQASEDLLKE HYTDLKDRPF FTGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVKSAEKEI SLWFQPEELV EYKSCAQ
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
NCBI and Uniprot Product Information
Uniprot Description
NME1: an enzyme with multiple activities including histidine protein kinase, nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase and 3'-5' exonuclease activities. Plays a major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Involved in cell proliferation, differentiation and development, G protein-coupled receptor endocytosis, cytotoxic T cell and NK cell-mediated cell death, and gene expression. Required for neural development including neural patterning and cell fate determination. During granzyme A (GZMA)-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Three alternatively spliced human proteins have been reported.
Protein type: EC 2.7.4.6; Kinase, nucleoside diphosphate; Kinase, other; NDK family; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other group; Protein kinase, histidine; Tumor suppressor
Chromosomal Location of Human Ortholog: 11|11 D
Cellular Component: centrosome; cytoplasm; cytosol; extracellular exosome; intermediate filament; membrane; mitochondrial outer membrane; mitochondrion; myelin sheath; nucleus; perinuclear region of cytoplasm
Molecular Function: ATP binding; deoxyribonuclease activity; enzyme binding; gamma-tubulin binding; GTP binding; identical protein binding; intermediate filament binding; kinase activity; magnesium ion binding; metal ion binding; nucleoside diphosphate kinase activity; nucleotide binding; protein kinase binding; ribosomal small subunit binding; RNA binding; single-stranded DNA binding; transferase activity
Biological Process: cell differentiation; CTP biosynthetic process; endocytosis; GTP biosynthetic process; lactation; mammary gland development; negative regulation of gene expression; negative regulation of myeloid leukocyte differentiation; nervous system development; nucleoside diphosphate phosphorylation; nucleotide metabolic process; phosphorylation; positive regulation of DNA binding; positive regulation of epithelial cell proliferation; positive regulation of neuron projection development; regulation of apoptosis; UTP biosynthetic process
Research Articles on NME1
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Product Notes
The NME1 nme1 (Catalog #AAA2007245) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the NME1 nme1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-RTF IA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF LQASEDLLKE HYTDLKDRPF FTGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVKSAEKEI SLWFQPEELV EYKSCAQ. It is sometimes possible for the material contained within the vial of "Non Metastatic Cells 1, Protein NM23A Expressed In (NME1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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