Rabbit anti-Human, Mouse NOD4 Polyclonal Antibody | anti-NOD4 antibody

NOD4 Antibody

Cat. Num. AAA9403605

• Gene Names: NLRC5; NOD4; NOD27; CLR16.1
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunocytochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: NOD4; Polyclonal Antibody; NOD4 Antibody; NLR family CARD domain containing 5; NLRC5; Caterpiller protein 16.1; NOD27; anti-NOD4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 1866

• Applicable Applications for anti-NOD4 antibody: ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against an 18 amino acid peptide near the amino terminus of human NOD4.
• Target Name: NOD4
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of NOD4 in EL4 cell lysate with NOD4 antibody at 1 ug/mL.)

Immunocytochemistry (ICC)

(Immunocytochemistry of NOD4 in HeLa cells with NOD4 antibody at 10 ug/mL.)

Related Product Information for anti-NOD4 antibody

NOD4 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD4 contains a CARD-like domain, a central NOD domain and a large LRR region. NOD4, an IFN-gamma-inducible nuclear protein, plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. As a key negative regulator of NF-kB and type I interferon signaling, NOD4 may be a useful target for manipulating immune responses against infectious or inflammation-associated diseases, including cancer.

Product Categories/Family for anti-NOD4 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 350529351
• NCBI GeneID: 84166
• NCBI Accession #: NP_115582
• NCBI GenBank Nucleotide #: NM_032206.4
• Molecular Weight: 170,417 Da
• NCBI Official Full Name: protein NLRC5
• NCBI Official Synonym Full Names: NLR family, CARD domain containing 5
• NCBI Official Symbol: NLRC5
• NCBI Official Synonym Symbols: NOD4; NOD27; CLR16.1
• NCBI Protein Information: protein NLRC5
• UniProt Protein Name: Protein NLRC5
• UniProt Gene Name: NLRC5
• UniProt Synonym Gene Names: NOD27; NOD4; CLR16.1
• UniProt Entry Name: NLRC5_HUMAN

NCBI Description

This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]

Uniprot Description

NLRC5: Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. Belongs to the NLRP family. 6 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; ATP binding

Biological Process: regulation of kinase activity; inhibition of NF-kappaB transcription factor; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of MHC class I biosynthetic process; defense response to virus; negative regulation of interferon type I production