Rabbit NOC2L Polyclonal Antibody | anti-NOC2L antibody

NOC2L (I634) Polyclonal Antibody

Cat. Num. AAA3003474

• Gene Names: NOC2L; NIR; NET7; NET15; PPP1R112
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: NOC2L; Polyclonal Antibody; NOC2L (I634) Polyclonal Antibody; Nucleolar complex protein 2 homolog; Protein NOC2 homolog; NOC2-like protein; Novel INHAT repressor; NIR; anti-NOC2L antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: NOC2L (I634) polyclonal antibody detects endogenous levels of NOC2L protein
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 749

• Applicable Applications for anti-NOC2L antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 602-650 of Human NOC2L.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of NOC2L (I634) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.)

Related Product Information for anti-NOC2L antibody

GADD 153, a growth arrest and DNA damage-inducible gene, encodes a C/EBP-related nuclear protein. This protein has also been designated C/EBP-homologous protein (CHOP-10 or C/EBP zeta). GADD 153 expression is induced by a variety of cellular stresses, inducing nutrient deprivation and metabolic perturbations. GADD 153 functions to block cells in G1 to S phase during cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD 153 dimers away from "classical" C/EBP binding sites, recognizing instead unique "nonclassical" sites. Thus, GADD 153 acts as a negative modulator of C/EBP-like proteins in certain terminally differentiated cells. GADD 153 belongs to the CBF/MAK21 family, which also includes NOC2L, NOC3L and NOC4L. NOC2L is a 749 amino acid nuclear protein that may play a role in cell cycle regulation.

NCBI and Uniprot Product Information

• NCBI GI #: 157694511
• NCBI GeneID: 26155
• NCBI Accession #: NP_056473.2
• NCBI GenBank Nucleotide #: NP_056473.2
• UniProt Accession #: Q9Y3T9
• Molecular Weight: ~ 85kDa
• NCBI Official Full Name: nucleolar complex protein 2 homolog
• NCBI Official Synonym Full Names: NOC2 like nucleolar associated transcriptional repressor
• NCBI Official Symbol: NOC2L
• NCBI Official Synonym Symbols: NIR; NET7; NET15; PPP1R112
• NCBI Protein Information: nucleolar complex protein 2 homolog
• UniProt Protein Name: Nucleolar complex protein 2 homolog
• UniProt Gene Name: NOC2L
• UniProt Synonym Gene Names: NIR; Protein NOC2 homolog
• UniProt Entry Name: NOC2L_HUMAN

NCBI Description

Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]

Uniprot Description

NOC2L: Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. Belongs to the NOC2 family.

Protein type: RNA-binding; Transcription factor; Histone-binding; Nucleolus

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: nucleoplasm; nucleolus; nucleus

Molecular Function: protein binding; histone binding; nucleosome binding; chromatin binding; transcription corepressor activity

Biological Process: nucleolus to nucleoplasm transport; transcription, DNA-dependent; apoptosis; chromatin assembly; negative regulation of transcription from RNA polymerase II promoter; negative regulation of B cell apoptosis; negative regulation of histone acetylation