Western Blot (WB)
(Western Blot analysis of Hela cell using NOC2L Polyclonal Antibody at dilution of 1:200)
Rabbit NOC2L Polyclonal Antibody | anti-NOC2L antibody
NOC2L Polyclonal Antibody
IHC: 1:25-1:100
Western Blot (WB)
(Western Blot analysis of Hela cell using NOC2L Polyclonal Antibody at dilution of 1:200)
Western Blot (WB)
(Western Blot analysis of Hela cell using NOC2L Polyclonal Antibody at dilution of 1:200)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human prostate cancer using NOC2L Polyclonal Antibody at dilution of 1:20)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human prostate cancer using NOC2L Polyclonal Antibody at dilution of 1:20)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human breast cancer using NOC2L Polyclonal Antibody at dilution of 1:20)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human breast cancer using NOC2L Polyclonal Antibody at dilution of 1:20)
NCBI and Uniprot Product Information
NCBI Description
Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]
Uniprot Description
NOC2L: Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. Belongs to the NOC2 family.
Protein type: Transcription factor; RNA-binding; Histone-binding; Nucleolus
Chromosomal Location of Human Ortholog: 1p36.33
Cellular Component: nucleoplasm; nucleolus; nucleus
Molecular Function: protein binding; histone binding; nucleosome binding; chromatin binding; transcription corepressor activity
Biological Process: nucleolus to nucleoplasm transport; transcription, DNA-dependent; apoptosis; chromatin assembly; negative regulation of transcription from RNA polymerase II promoter; negative regulation of B cell apoptosis; negative regulation of histone acetylation
Research Articles on NOC2L
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Product Notes
The NOC2L noc2l (Catalog #AAA2524664) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NOC2L Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NOC2L can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). WB: 1:200-1:1000 IHC: 1:25-1:100. Researchers should empirically determine the suitability of the NOC2L noc2l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NOC2L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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