Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human prostate cancer using NME2 Polyclonal Antibody at dilution of 1/40)
Rabbit NME2 Polyclonal Antibody | anti-NME2 antibody
NME2 Polyclonal Antibody
IHC: 1:30-150
WB: 1:1000-5000
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human prostate cancer using NME2 Polyclonal Antibody at dilution of 1/40)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human prostate cancer using NME2 Polyclonal Antibody at dilution of 1/40)
Western Blot (WB)
(Western Blot analysis of Hela, NIH/3T3, LNCap and 293T cells, Mouse brain tissue, A549 and Jurkat cells using NME2 Polyclonal Antibody at dilution of 1/300)
Western Blot (WB)
(Western Blot analysis of Hela, NIH/3T3, LNCap and 293T cells, Mouse brain tissue, A549 and Jurkat cells using NME2 Polyclonal Antibody at dilution of 1/300)
NCBI and Uniprot Product Information
NCBI Description
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
Uniprot Description
NME2: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Belongs to the NDK family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.13.3; EC 2.7.4.6; Kinase, nucleoside diphosphate; Kinase, other; NDK family; Nuclear receptor co-regulator; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other group
Chromosomal Location of Human Ortholog: 17q21.3
Cellular Component: cytoplasm; cytosol; focal adhesion; lamellipodium; nucleus; ruffle
Molecular Function: nucleoside diphosphate kinase activity; protein binding; transcription factor activity
Biological Process: cell adhesion; integrin-mediated signaling pathway; negative regulation of apoptosis; nucleobase, nucleoside and nucleotide interconversion; nucleoside triphosphate biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; purine nucleotide metabolic process; pyrimidine nucleotide metabolic process; regulation of epidermis development; regulation of transcription, DNA-dependent
Research Articles on NME2
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Product Notes
The NME2 nme2 (Catalog #AAA2542861) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NME2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NME2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). ELISA: 1:2000-10000 IHC: 1:30-150 WB: 1:1000-5000. Researchers should empirically determine the suitability of the NME2 nme2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NME2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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