Rabbit anti-Human NMDAepsilon3 Polyclonal Antibody | anti-NMDAepsilon3 antibody

NMDAepsilon3 Antibody

Cat. Num. AAA9508959

• Gene Names: GRIN2C; NR2C; GluN2C; NMDAR2C
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Synonyms: NMDAepsilon3; Polyclonal Antibody; NMDAepsilon3 Antibody; Glutamate NMDA receptor subunit epsilon 3 precursor; GRIN2C; N-methyl D-aspartate receptor subtype 2C; NMDE3; NR2C; NMDAR2C; anti-NMDAepsilon3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: NMDAepsilon3 antibody detects endogenous levels of NMDAepsilon3.
• Purity/Purification: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1,233

• Applicable Applications for anti-NMDAepsilon3 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50~1:100; ELISA: 1:10000
• Target Modification: Unmodified/Total
• Immunogen: The antiserum was produced against synthesized peptide derived from human NMDAepsilon3.
• Immunogen Range: 937-986
• Preparation and Storage: Stable at -20 degree C for at least 1 year.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of NMDAepsilon3 antibody in paraffin-embedded human brain tissue.)

NCBI and Uniprot Product Information

• NCBI GI #: 55770854
• NCBI GeneID: 2905
• NCBI Accession #: NP_000826.2
• NCBI GenBank Nucleotide #: NM_000835.4
• UniProt Accession #: Q14957; B2RTT1
• Molecular Weight: 134 kDa
• NCBI Official Full Name: glutamate receptor ionotropic, NMDA 2C isoform 1
• NCBI Official Synonym Full Names: glutamate ionotropic receptor NMDA type subunit 2C
• NCBI Official Symbol: GRIN2C
• NCBI Official Synonym Symbols: NR2C; GluN2C; NMDAR2C
• NCBI Protein Information: glutamate receptor ionotropic, NMDA 2C
• UniProt Protein Name: Glutamate receptor ionotropic, NMDA 2C
• UniProt Gene Name: GRIN2C
• UniProt Synonym Gene Names: NMDAR2C; GluN2C; NMDAR2C; NR2C

NCBI Description

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Uniprot Description

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning ().