Rabbit anti-Human NLRP4 Polyclonal Antibody | anti-NLRP4 antibody

NLRP4 Antibody

Cat. Num. AAA9406710

• Gene Names: NLRP4; CT58; PAN2; RNH2; NALP4; PYPAF4; CLR19.5
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: NLRP4; Polyclonal Antibody; NLRP4 Antibody; CT58; PAN2; RNH2; NALP4; PYPAF4; CLR19.5; anti-NLRP4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total NLRP4 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.8 mg/ml (varies by lot)
• Sequence Length: 994

• Applicable Applications for anti-NLRP4 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human NLR family, pyrin domain containing 4
• Target Name: NLRP4
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/40.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue using at dilution 1/40.)

Related Product Information for anti-NLRP4 antibody

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes

Product Categories/Family for anti-NLRP4 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 194018482
• NCBI GeneID: 147945
• NCBI Accession #: NP_604393.2
• NCBI GenBank Nucleotide #: NM_134444.4
• UniProt Accession #: Q96MN2; Q86W87; Q96AY6
• Molecular Weight: 103,968 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 4
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 4
• NCBI Official Symbol: NLRP4
• NCBI Official Synonym Symbols: CT58; PAN2; RNH2; NALP4; PYPAF4; CLR19.5
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 4
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 4
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP4
• UniProt Synonym Gene Names: NALP4; PAN2; PYPAF4; RNH2; CT58; PAN2; PYPAF4
• UniProt Entry Name: NALP4_HUMAN

NCBI Description

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

Uniprot Description

NALP4: May be involved in inflammation. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: cytosol

Molecular Function: ATP binding

Biological Process: regulation of interferon type I production; positive regulation of interferon type I production; innate immune response; inflammatory response