Rabbit NLRP11 Polyclonal Antibody | anti-NLRP11 antibody

NLRP11 Polyclonal Antibody

Cat. Num. AAA9132045

• Gene Names: NLRP11; NOD17; PAN10; NALP11; PYPAF6; PYPAF7; CLR19.6
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: NLRP11; Polyclonal Antibody; NLRP11 Polyclonal Antibody; CLR19.6; NALP11; NOD17; PAN10; PYPAF6; PYPAF7; anti-NLRP11 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Sequence Length: 1033

• Applicable Applications for anti-NLRP11 antibody: Western Blot (WB)
• Application Notes: WB: 1:500 - 1:2000
• Immunogen: Recombinant protein of human NLRP11
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using NLRP11 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 1s.)

Related Product Information for anti-NLRP11 antibody

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).

Product Categories/Family for anti-NLRP11 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 288558818
• NCBI GeneID: 204801
• UniProt Accession #: P59045; Q2TV85; Q2TV86; Q53ZZ0; Q8NBF5; C9JSF5
• Molecular Weight: 118kDa
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 11
• NCBI Official Synonym Full Names: NLR family pyrin domain containing 11
• NCBI Official Symbol: NLRP11
• NCBI Official Synonym Symbols: NOD17; PAN10; NALP11; PYPAF6; PYPAF7; CLR19.6
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 11
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 11
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP11
• UniProt Synonym Gene Names: NALP11; NOD17; PAN10; PYPAF6

NCBI Description

This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017]

Uniprot Description

NLRP11: Involved in inflammation (Potential). Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.42-q13.43

Molecular Function: RNA binding