Human IL-33 ELISA Kit | IL-33 elisa kit

IL-33 (Human) OmniKine ELISA Kit

Cat. Num. AAA9501864

• Gene Names: IL33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26
• Reactivity: Human
• Synonyms: IL-33; IL-33 (Human) OmniKine ELISA Kit; Interleukin-33; Interleukin-1 family member 11; Nuclear factor from high endothelial venules; NF-HEV; IL-1F11; IL-33 elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human IL-33 ELISA is capable of recognizing both recombinant and naturally produced Human IL-33 proteins. The antigens listed below were tested at 50 ng/ml and exhibited less than 2% cross reactivity.; Murine: IL-33; The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.; Human: IFN-gamma, IL-1alpha, IL-1beta, IL-4, IL-5, IL-13, IL-13 Variant
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 228

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 32-4000 pg/ml
• Sensitivity: 32-4000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human IL-33 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human IL-33 proteins within the range of 32-4000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 313851030
• NCBI GeneID: 90865
• NCBI Accession #: NP_001186569.1
• NCBI GenBank Nucleotide #: NM_001199640.1
• UniProt Accession #: O95760; Q2YEJ5; B2R8L1; B4DJ35; B4E1Q9; D3DRI5; E7EAX4
• Molecular Weight: 16,250 Da
• NCBI Official Full Name: interleukin-33 isoform b
• NCBI Official Synonym Full Names: interleukin 33
• NCBI Official Symbol: IL33
• NCBI Official Synonym Symbols: DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26
• NCBI Protein Information: interleukin-33
• UniProt Protein Name: Interleukin-33
• UniProt Gene Name: IL33
• UniProt Synonym Gene Names: C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV

NCBI Description

The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Uniprot Description

IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: chromosome; cytosol; extracellular region; extracellular space; nucleoplasm; transport vesicle

Molecular Function: cytokine activity; protein binding

Biological Process: defense response to virus; microglial cell activation involved in immune response; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; negative regulation of leukocyte migration; negative regulation of T-helper 1 type immune response; positive regulation of immunoglobulin secretion; positive regulation of inflammatory response; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of interleukin-6 production; positive regulation of macrophage activation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type 2 immune response; protein deubiquitination; transcription, DNA-dependent; type 2 immune response