Rabbit anti-Human NALP11 Polyclonal Antibody | anti-NLRP11 antibody

NALP11, CT (NACHT, LRR and PYD Domains-containing Protein 11, Nucleotide-binding Oligomerization Domain Protein 17, PAAD-and NACHT Domain-containing Protein 10, PYRIN-containing APAF1-like Protein 6, NLRP11, NOD17, PAN10, PYPAF6)

Cat. Num. AAA6005440

• Gene Names: NLRP11; NOD17; PAN10; NALP11; PYPAF6; PYPAF7; CLR19.6
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: NALP11; Polyclonal Antibody; CT (NACHT; LRR and PYD Domains-containing Protein 11; Nucleotide-binding Oligomerization Domain Protein 17; PAAD-and NACHT Domain-containing Protein 10; PYRIN-containing APAF1-like Protein 6; NLRP11; NOD17; PAN10; PYPAF6); Anti -NALP11; anti-NLRP11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human NLRP11.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-NLRP11 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: Western Blot: 1-2ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to 15aa from human NALP11 at C-terminus.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-NLRP11 antibody

NALP11 is a 1033aa containing cytoplasmic protein belonging to the NLRP family with aDPIN domain, six LRR (leucine-rich) repeats and a NACHT domain. Reports suggest that it is a short NALP involved in inflammation potential. NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes. TheDPIN domain is necessary and sufficient for suppression of NF-kappa B activation induced by TNF and for inducing IL-1B secretion in collaboration with Caspase-1. It is involved in interaction with PYCARD.

Product Categories/Family for anti-NLRP11 antibody

Antibodies; Abs to Inflammasomes

NCBI and Uniprot Product Information

• NCBI GI #: 194018484
• NCBI GeneID: 204801
• NCBI Accession #: NP_659444.2
• NCBI GenBank Nucleotide #: NM_145007.3
• UniProt Accession #: P59045; Q2TV85; Q2TV86; Q53ZZ0; Q8NBF5; C9JSF5
• Molecular Weight: 117,779 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 11
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 11
• NCBI Official Symbol: NLRP11
• NCBI Official Synonym Symbols: NOD17; PAN10; NALP11; PYPAF6; PYPAF7; CLR19.6
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 11; PAAD- and NACHT-containing protein 10; PYRIN-containing APAF1-like protein 6; PAAD- and NACHT-containing protein 10B; NACHT, LRR and PYD containing protein 11; PAAD-and NACHT domain-containing protein 10; NACHT, leucine rich repeat and PYD containing 11; nucleotide-binding oligomerization domain protein 17; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 11
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 11
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP11
• UniProt Synonym Gene Names: NALP11; NOD17; PAN10; PYPAF6
• UniProt Entry Name: NAL11_HUMAN

NCBI Description

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

Uniprot Description

NLRP11: Involved in inflammation (Potential). Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.43

Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen; ATP binding