Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human tonsil tissue using NLRC4 Polyclonal Antibody at dilution of 1:50(×200))
Rabbit anti-Human NLRC4 Polyclonal Antibody | anti-NLRC4 antibody
NLRC4 Polyclonal Antibody
ELISA: 1:5000-1:10000
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human tonsil tissue using NLRC4 Polyclonal Antibody at dilution of 1:50(×200))
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human tonsil tissue using NLRC4 Polyclonal Antibody at dilution of 1:50(×200))
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human prost ate cancer tissue using NLRC4 Polyclonal Antibody at dilution of 1:50(×200))
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human prost ate cancer tissue using NLRC4 Polyclonal Antibody at dilution of 1:50(×200))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Description
NLRC4: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 2p22.3
Cellular Component: spindle microtubule; cytoplasm; intracellular; nucleus; cytosol
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; ubiquitin-protein ligase activity; magnesium ion binding; cysteine protease inhibitor activity; ATP binding
Biological Process: caspase activation; detection of bacterium; positive regulation of apoptosis; regulation of signal transduction; protein ubiquitination; activation of NF-kappaB transcription factor; regulation of neuron apoptosis; defense response to bacterium; innate immune response; interleukin-1 beta secretion; inflammatory response; activation of innate immune response; protein homooligomerization; negative regulation of apoptosis
Disease: Autoinflammation With Infantile Enterocolitis; Familial Cold Autoinflammatory Syndrome 4
Research Articles on NLRC4
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Product Notes
The NLRC4 nlrc4 (Catalog #AAA2562085) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NLRC4 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NLRC4 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA). IHC: 1:50-1:200 ELISA: 1:5000-1:10000. Researchers should empirically determine the suitability of the NLRC4 nlrc4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NLRC4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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