Rabbit anti-Human NLGN4Y Polyclonal Antibody | anti-NLGN4Y antibody

NLGN4Y, NT (NLGN4Y, KIAA0951, Neuroligin-4, Y-linked) (Biotin)

Cat. Num. AAA6325699

• Gene Names: NLGN4Y; HNL4Y
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: NLGN4Y; Polyclonal Antibody; NT (NLGN4Y; KIAA0951; Neuroligin-4; Y-linked) (Biotin); Y-linked; anti-NLGN4Y antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Sequence Length: 816

• Applicable Applications for anti-NLGN4Y antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: NLGN4Y antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the N-terminal region of human NLGN4Y.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(NLGN4Y Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the NLGN4Y antibody detected the NLGN4Y protein (arrow).)

Related Product Information for anti-NLGN4Y antibody

Neuroligins, such as NLGN4Y, are cell adhesion molecules present at the postsynaptic side of the synapse and may be essential for the formation of functional synapses (Jamain et al., 2003 [PubMed 12669065]).

Product Categories/Family for anti-NLGN4Y antibody

Antibodies; Neuroligins

References

Serajee, F.J., et al. J. Child Neurol. 24(10):1258-1261(2009). Yan, J., et al. Psychiatr. Genet. 18(4):204-207(2008). Yamakawa, H., et al. Biochem. Biophys. Res. Commun. 355(1):41-46(2007). Ylisaukko-oja, T., et al. Eur. J. Hum. Genet. 13(12):1285-1292(2005). Skaletsky, H., et al. Nature 423(6942):825-837(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 256222771
• NCBI GeneID: 22829
• NCBI Accession #: NP_055708.3; NP_001157710.1
• NCBI GenBank Nucleotide #: NP_055708.3
• UniProt Accession #: Q8NFZ3
• NCBI Official Full Name: neuroligin-4, Y-linked isoform 1
• NCBI Official Synonym Full Names: neuroligin 4 Y-linked
• NCBI Official Symbol: NLGN4Y
• NCBI Official Synonym Symbols: HNL4Y
• NCBI Protein Information: neuroligin-4, Y-linked
• UniProt Protein Name: Neuroligin-4, Y-linked
• Protein Family: Neuroligin
• UniProt Gene Name: NLGN4Y
• UniProt Synonym Gene Names: KIAA0951; Neuroligin Y
• UniProt Entry Name: NLGNY_HUMAN

NCBI Description

This gene encodes a type I membrane protein that belongs to the family of neuroligins, which are cell adhesion molecules present at the postsynaptic side of the synapse, and may be essential for the formation of functional synapses. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Mar 2011]

Uniprot Description

NLGN4Y: Putative neuronal cell surface protein involved in cell- cell-interactions. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Yq11.221

Cellular Component: postsynaptic membrane; extracellular space; cell surface; integral to plasma membrane; postsynaptic density; synapse; cell junction

Molecular Function: protein binding; neurexin binding; receptor activity; cell adhesion molecule binding

Biological Process: regulation of synaptic transmission; synaptogenesis; metabolic process; neuron adhesion; social behavior; learning