Western Blot (WB)
(NKAP Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NKAP antibody detected the NKAP protein (arrow).)
Rabbit NKAP Polyclonal Antibody | anti-NKAP antibody
NKAP Antibody (C-term)
Western Blot (WB)
(NKAP Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NKAP antibody detected the NKAP protein (arrow).)
Western Blot (WB)
(NKAP Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NKAP antibody detected the NKAP protein (arrow).)
activation of the ubiquitous transcription factor NF-kappaB. This
protein is associated with the the histone deacetylase HDAC3 and
with the Notch corepressor complex, and it thereby acts as a
transcriptional repressor of Notch target genes. It is also
required for alphabeta T cell development. A related pseudogene has
been identified on chromosome X, while a related and intronless
retrocopy, which has an intact CDS and may be functional, is
located on chromosome 6.
Pajerowski, A.G., et al. Immunity 30(5):696-707(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Chen, D., et al. Biochem. Biophys. Res. Commun. 310(3):720-724(2003)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]
Uniprot Description
NKAP: Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. Belongs to the UPF0396 family.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: nucleoplasm; cytoplasm
Molecular Function: protein binding; chromatin DNA binding; chromatin binding
Biological Process: Notch signaling pathway; transcription, DNA-dependent; granulocyte differentiation; stem cell maintenance; T cell differentiation in the thymus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of alpha-beta T cell differentiation
Research Articles on NKAP
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Product Notes
The NKAP nkap (Catalog #AAA9212726) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 387-415. The NKAP Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's NKAP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the NKAP nkap for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NKAP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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