Rabbit NHP2L1 Polyclonal Antibody | anti-SNU13 antibody
NHP2L1 Antibody
Gene Names
NHP2L1; FA1; FA-1; NHPX; 15.5K; OTK27; SNU13; SSFA1; SPAG12; SNRNP15-5
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
NHP2L1; Polyclonal Antibody; NHP2L1 Antibody; [U4/U6.U5] tri snRNP; 15.5 kD RNA binding protein; High mobility group like nuclear protein 2 homolog 1; hSNU13; NHP2 non histone chromosome protein 2 like 1 (S. cerevisiae); NHP2L 1; NHPX; OTK27; SNU13; anti-SNU13 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
NHP2L1 Antibody detects endogenous levels of total NHP2L1.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-SNU13 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from Human MYOCD.
Conjugation
Unconjugated
Similarity
Belongs to the eukaryotic ribosomal protein eL8 family.
Subunit Structure
Identified in the spliceosome B complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Interacts with RAD17 and PRPF31. The complex formed by SNU13 and PRPF31 binds U4 snRNA. The complex formed by SNU13 and PRPF31 binds also U4atac snRNA, a characteristic component of specific, less abundant spliceosomal complexes.
Tissue Specificity
Ubiquitous.
Function
Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.
Note
Concentrated in the dense fibrillar component of the nucleolus.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
14,174 Da
NCBI Official Full Name
NHP2-like protein 1
NCBI Official Synonym Full Names
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
NCBI Official Symbol
NHP2L1
NCBI Official Synonym Symbols
FA1; FA-1; NHPX; 15.5K; OTK27; SNU13; SSFA1; SPAG12; SNRNP15-5
NCBI Protein Information
NHP2-like protein 1; U4/U6.U5 tri-snRNP 15.5 kDa protein; [U4/U6.U5] tri-snRNP 15.5 kD RNA binding protein; high mobility group-like nuclear protein 2 homolog 1; non-histone chromosome protein 2-like 1; small nuclear ribonucleoprotein 15.5kDa (U4/U6.U5);
UniProt Protein Name
NHP2-like protein 1
Protein Family
UniProt Gene Name
NHP2L1
UniProt Synonym Gene Names
hSNU13
UniProt Entry Name
NH2L1_HUMAN
NCBI Description
Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
NHP2L1: Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. Belongs to the ribosomal protein L7Ae family.
Protein type: RNA splicing; Nucleolus; Spliceosome; RNA-binding
Chromosomal Location of Human Ortholog: 22q13
Cellular Component: nucleoplasm; spliceosome; protein complex; nucleolus; nucleus
Molecular Function: snoRNA binding; protein binding; RNA binding
Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; ribosome biogenesis and assembly; gene expression
Research Articles on SNU13
Similar Products
Product Notes
The SNU13 nhp2l1 (Catalog #AAA9629430) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NHP2L1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NHP2L1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the SNU13 nhp2l1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NHP2L1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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