Rabbit NFATC4/NFAT3 Polyclonal Antibody | anti-NFATC4/NFAT3 antibody

Anti-NFATC4/NFAT3 Antibody (aa136-185)

Cat. Num. AAA2401063

• Gene Names: NFATC4; NFAT3; NF-AT3; NF-ATC4
• Reactivity: Human; Predicted: Mouse
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: NFATC4/NFAT3; Polyclonal Antibody; Anti-NFATC4/NFAT3 Antibody (aa136-185); Goat Polyclonal to Human NFATC4/NFAT3; NFATC4; NF-ATc4; NFAT3; NF-AT3; anti-NFATC4/NFAT3 antibody

• Host: Rabbit
• Reactivity: Human; Predicted: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: NFAT3 Antibody detects endogenous levels of total NFAT3 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Sequence Length: 902

• Applicable Applications for anti-NFATC4/NFAT3 antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: ELISA: 1:1000; IHC-P: 1:50; WB: 1:500-1:1000
• Immunogen: Synthetic peptide from human NFAT3 (aa136-185).
• Conjugation: Unconjugated
• Epitope: aa136-185
• Preparation and Storage: Store at -20 degree C for up to one year.

Immunohistochemistry (IHC)

(Anti-NFATC4/NFAT3 antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.)

Western Blot (WB)

(Western blot of extracts from Jurkat cells, using NFAT3 Antibody. The lane on the right is treated with the synthesized peptide.)

Related Product Information for anti-NFATC4/NFAT3 antibody

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionallyrepressed by estrogen receptors; this inhibition is further enhanced byestrogen. Increases the transcriptional activity of PPARG and has adirect role in adipocyte differentiation. May play an important role inmyotube differentiation. May play a critical role in cardiac development and hypertrophy.

NCBI and Uniprot Product Information

• NCBI GI #: 27886563
• NCBI GeneID: 4776
• NCBI Accession #: NP_004545.2
• NCBI GenBank Nucleotide #: NM_004554.4
• UniProt Accession #: Q14934; B4DDG5; B4DY55; B5B2U7; B5B2U8; B5B2U9; B5B2V0; B5B2V1; B5B2V2; B5B2V3; B5B2V4; B5B2V5
• Molecular Weight: 8,950 Da
• NCBI Official Full Name: nuclear factor of activated T-cells, cytoplasmic 4 isoform 2
• NCBI Official Synonym Full Names: nuclear factor of activated T cells 4
• NCBI Official Symbol: NFATC4
• NCBI Official Synonym Symbols: NFAT3; NF-AT3; NF-ATC4
• NCBI Protein Information: nuclear factor of activated T-cells, cytoplasmic 4
• UniProt Protein Name: Nuclear factor of activated T-cells, cytoplasmic 4
• UniProt Gene Name: NFATC4
• UniProt Synonym Gene Names: NFAT3; NF-ATc4; NFATc4; NF-AT3

NCBI Description

This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Description

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.