Goat NFATC4 Polyclonal Antibody | anti-NFATC4 antibody

NFATC4 (Nuclear Factor of Activated T-cells, Cytoplasmic 4, NF-ATc4, NFATc4, T-cell Transcription Factor NFAT3, NF-AT3, NFAT3)

Cat. Num. AAA6007796

• Gene Names: NFATC4; NFAT3; NF-ATc4
• Reactivity: Canine, Human, Mouse, Porcine, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: NFATC4; Polyclonal Antibody; NFATC4 (Nuclear Factor of Activated T-cells; Cytoplasmic 4; NF-ATc4; NFATc4; T-cell Transcription Factor NFAT3; NF-AT3; NFAT3); Anti -NFATC4 (Nuclear Factor of Activated T-cells; anti-NFATC4 antibody

• Host: Goat
• Reactivity: Canine, Human, Mouse, Porcine, Rat
• Clonality: Polyclonal
• Specificity: Recognizes human NFATC4. Species sequence homology: Canine, mouse, rat and porcine.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

• Applicable Applications for anti-NFATC4 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:16,000; Immunohistochemistry (paraffin): 2.5-3.8ug/ml
• Immunogen: Synthetic peptide corresponding to C-SGFPAPPGEEPPA, from NFATC4, at C-terminal (NP_004545.2).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin embedded human placenta using MBS6007796 (3.8ug/ml). Steamed antigen retrieval with citrate buffer pH 6, AP-staining.)

Related Product Information for anti-NFATC4 antibody

The protein is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.

Product Categories/Family for anti-NFATC4 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 27886563
• NCBI GeneID: 4776
• NCBI Accession #: NP_004545.2
• NCBI GenBank Nucleotide #: NM_004554.4
• UniProt Accession #: Q14934; B4DDG5; B4DY55; B5B2U7; B5B2U8; B5B2U9; B5B2V0; B5B2V1; B5B2V2; B5B2V3; B5B2V4; B5B2V5
• Molecular Weight: 95,449 Da
• NCBI Official Full Name: nuclear factor of activated T-cells, cytoplasmic 4 isoform 2
• NCBI Official Synonym Full Names: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
• NCBI Official Symbol: NFATC4
• NCBI Official Synonym Symbols: NFAT3; NF-ATc4
• NCBI Protein Information: nuclear factor of activated T-cells, cytoplasmic 4; NF-AT3; T cell transcription factor NFAT3; T-cell transcription factor NFAT3
• UniProt Protein Name: Nuclear factor of activated T-cells, cytoplasmic 4
• Protein Family: Nuclear factor of activated T-cells
• UniProt Gene Name: NFATC4
• UniProt Synonym Gene Names: NFAT3; NF-ATc4; NFATc4; NF-AT3
• UniProt Entry Name: NFAC4_HUMAN

NCBI Description

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Oct 2008]

Uniprot Description

NFAT3: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. 23 alternatively spliced isoforms of the human protein hve been reported. Note: This description may include information from UniProtKB

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: intermediate filament cytoskeleton; transcription factor complex; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; peroxisome proliferator activated receptor binding; transcription coactivator activity; transcription factor binding

Biological Process: patterning of blood vessels; transcription from RNA polymerase II promoter; DNA damage response, signal transduction resulting in induction of apoptosis; heart development; cellular respiration; muscle cell development; regulation of synaptic plasticity; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; inflammatory response; positive regulation of tumor necrosis factor production