Rabbit anti-Human, Mouse NFAT5 Polyclonal Antibody | anti-NFAT5 antibody

Rabbit Polyclonal (IgG) to Human NFAT5

Cat. Num. AAA242908

• Gene Names: NFAT5; NFATZ; OREBP; NF-AT5; NFATL1; TONEBP
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: NFAT5; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human NFAT5; Anti-NFAT5 Antibody (aa1171-1220) IHC-plus; NFAT-like protein 1; NFATZ; OREBP; KIAA0827; TonE-binding protein; TONEBP; Glutamine rich protein H65; NF-AT5; NFATL1; Human NFAT5; anti-NFAT5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: NFAT5 (Ab-1197) Antibody detects endogenous levels of total NFAT5 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1531

• Applicable Applications for anti-NFAT5 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:1000), IHC-P (10 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide from human NFAT5 (aa1171-1220).
• Immunogen: NFAT5 antibody was raised against synthetic peptide from human NFAT5 (aa1171-1220).
• Antigen Modification: aa1171-1220
• Preparation and Storage: Store at -20 degree C for up to one year.

Immunohistochemistry (IHC)

(Anti-NFAT5 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Related Product Information for anti-NFAT5 antibody

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements.

Product Categories/Family for anti-NFAT5 antibody

Family: Transcription factor

NCBI and Uniprot Product Information

• NCBI GI #: 5729945
• NCBI GeneID: 10725
• NCBI Accession #: NP_006590.1
• NCBI GenBank Nucleotide #: NM_006599.3
• UniProt Accession #: O94916; O95693; Q7LA65; Q969Q8; Q96QH3; Q9UN18; A2RRB4; A6H8V5; E9PHR7
• Molecular Weight: 167,808 Da
• NCBI Official Full Name: nuclear factor of activated T-cells 5 isoform c
• NCBI Official Synonym Full Names: nuclear factor of activated T-cells 5, tonicity-responsive
• NCBI Official Symbol: NFAT5
• NCBI Official Synonym Symbols: NFATZ; OREBP; NF-AT5; NFATL1; TONEBP
• NCBI Protein Information: nuclear factor of activated T-cells 5; NFAT-like protein 1; TonE-binding protein; glutamine rich protein H65; T-cell transcription factor NFAT5; osmotic response element-binding protein; tonicity-responsive enhancer-binding protein
• UniProt Protein Name: Nuclear factor of activated T-cells 5
• Protein Family: Nuclear factor of activated T-cells
• UniProt Gene Name: NFAT5
• UniProt Synonym Gene Names: KIAA0827; TONEBP; NF-AT5; TonE-binding protein; TonEBP
• UniProt Entry Name: NFAT5_HUMAN

NCBI Description

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

NFAT5: Plays a role in the inducible expression of genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. Homodimer when bound to DNA, completely encircles its DNA target. Does not bind with Fos and Jun transcription factors. Highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes. Also expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; cytokine production; positive regulation of transcription from RNA polymerase II promoter; excretion; signal transduction