Rabbit NFASC Polyclonal Antibody | anti-NFASC antibody

NFASC antibody

Cat. Num. AAA9409132

• Gene Names: NFASC; NF; NRCAML
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: NFASC; Polyclonal Antibody; NFASC antibody; NF; NRCAML; anti-NFASC antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total NFASC antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 1240

• Applicable Applications for anti-NFASC antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunohistochemistry: 1:50 - 1:100
• Immunogen Type: Peptide
• Immunogen Description: A synthetic peptide of human NFASC.
• Target Name: NFASC
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of A549 cell lysate, using NFASC antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded Human brain tissue using NFASC antibody.)

Related Product Information for anti-NFASC antibody

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.

Product Categories/Family for anti-NFASC antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 237858675
• NCBI GeneID: 23114
• NCBI Accession #: NP_001005388.2
• NCBI GenBank Nucleotide #: NM_001005388.2
• UniProt Accession #: O94856; Q149P5; Q5T2F0; Q5T2F1; Q5T2F2; Q5T2F3; Q5T2F4; B2RNN8; B3KQZ1; B5MDP6; B5MDR6; B7ZMD8
• Molecular Weight: 142,474 Da
• NCBI Official Full Name: neurofascin isoform 1
• NCBI Official Synonym Full Names: neurofascin
• NCBI Official Symbol: NFASC
• NCBI Official Synonym Symbols: NF; NRCAML
• NCBI Protein Information: neurofascin
• UniProt Protein Name: Neurofascin
• Protein Family: Neurofascin
• UniProt Gene Name: NFASC
• UniProt Synonym Gene Names: KIAA0756
• UniProt Entry Name: NFASC_HUMAN

NCBI Description

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]

Uniprot Description

neurofascin: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 13 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: focal adhesion; paranode region of axon; integral to membrane; plasma membrane; intracellular

Molecular Function: protein binding

Biological Process: myelination; axon guidance; heterotypic cell-cell adhesion; clustering of voltage-gated sodium channels; synapse organization and biogenesis; transmission of nerve impulse; paranodal junction assembly; peripheral nervous system development