Rabbit Neuroserpin Polyclonal Antibody | anti-SERPINI1 antibody

Neuroserpin Rabbit Polyclonal

Cat. Num. AAA7601914

• Gene Names: SERPINI1; PI12; neuroserpin
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: Neuroserpin; Polyclonal Antibody; Neuroserpin Rabbit Polyclonal; anti-SERPINI1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 410

• Applicable Applications for anti-SERPINI1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Serpin peptidase inhibitor, clade I (neuroserpin), member 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7601914 (Neuroserpin antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 170295807
• NCBI GeneID: 5274
• NCBI Accession #: NP_001116224.1
• NCBI GenBank Nucleotide #: NM_001122752.1
• Molecular Weight: 46,427 Da
• NCBI Official Full Name: neuroserpin
• NCBI Official Synonym Full Names: serpin family I member 1
• NCBI Official Symbol: SERPINI1
• NCBI Official Synonym Symbols: PI12; neuroserpin
• NCBI Protein Information: neuroserpin
• UniProt Protein Name: Neuroserpin
• Protein Family: Neuroserpin
• UniProt Gene Name: SERPINI1
• UniProt Synonym Gene Names: PI12; PI-12
• UniProt Entry Name: NEUS_HUMAN

NCBI Description

This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

SERPINI1: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: central nervous system development; peripheral nervous system development; regulation of cell adhesion

Disease: Encephalopathy, Familial, With Neuroserpin Inclusion Bodies