Rabbit anti-Human Neuropeptide Y2 Receptor Polyclonal Antibody | anti-NPY2R antibody

Neuropeptide Y2 Receptor (NPY Y2R)

Cat. Num. AAA611293

• Gene Names: NPY2R; NPY2R
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Neuropeptide Y2 Receptor; Polyclonal Antibody; Neuropeptide Y2 Receptor (NPY Y2R); Anti -Neuropeptide Y2 Receptor (NPY Y2R); anti-NPY2R antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NPY Y2R. Species Sequence Homology: monkey, mouse, rat - 85%.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 40% glycerol.

• Applicable Applications for anti-NPY2R antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 0.5-1ug/ml; Control peptide (N2176-63P) can be used to coat ELISA plates at 1ug/ml.; Western Blot: 1-10ug/ml (ECL)
• Immunogen: Synthetic peptide corresponding to 14aa from the ~C-terminus, Cytoplasmic domain of human NPY Y2R (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-NPY2R antibody

Neuropeptide Y (NPY), a neuropeptide colocalized and abundantly released with the neurotransmitter norepinephrine in nervous system, synthesized by postnatal olfactory epithelium of sustentacular cells. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. NPY a 97aa peptide in mouse, human (chr 7p15.1) and 98aa in rat has a mol. wt of 11kD. NPY shows sequence homology to Peptide YY (PYY) and over 50% homology in amino acid and nucleotide sequence to Pancreatic Polypeptide (PNP or PPY), all of these homologous peptides has a 36aa mature peptide characterized by a hairpin loop.

Product Categories/Family for anti-NPY2R antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 1174046
• NCBI GeneID: 4887
• UniProt Accession #: P49146; Q13281; Q13457; Q4W5G7; Q6AZZ6; Q9UE67
• Molecular Weight: 42,731 Da
• NCBI Official Full Name: neuropeptide y2 receptor
• NCBI Official Synonym Full Names: neuropeptide Y receptor Y2
• NCBI Official Symbol: NPY2R
• NCBI Official Synonym Symbols: NPY2R
• NCBI Protein Information: neuropeptide Y receptor type 2; NPY2-R; Y2 receptor; NPY-Y2 receptor; OTTHUMP00000220313; OTTHUMP00000220314
• UniProt Protein Name: Neuropeptide Y receptor type 2
• Protein Family: Neuropeptide Y receptor
• UniProt Gene Name: NPY2R
• UniProt Entry Name: NPY2R_HUMAN

Uniprot Description

NPY2R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: nonmotile primary cilium; integral to plasma membrane; plasma membrane

Molecular Function: peptide YY receptor activity; protein binding; calcium channel regulator activity; neuropeptide Y receptor activity; receptor activity

Biological Process: positive regulation of dopamine secretion; secretion; positive regulation of cell adhesion; behavioral fear response; negative regulation of synaptic transmission, glutamatergic; positive regulation of peptide secretion; locomotory behavior; negative regulation of cAMP biosynthetic process; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; negative regulation of secretion; G-protein signaling, adenylate cyclase inhibiting pathway; positive regulation of smooth muscle contraction; regulation of sensory perception of pain; nitric oxide mediated signal transduction; negative regulation of neurological process; positive regulation of circadian sleep/wake cycle, non-REM sleep