Rabbit anti-Human, Mouse NPY2R Polyclonal Antibody | anti-NPY2R antibody

NPY2R, NT (NPY2R, Neuropeptide Y receptor type 2, NPY-Y2 receptor) (AP)

Cat. Num. AAA6326435

• Gene Names: NPY2R; NPY2-R
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: NPY2R; Polyclonal Antibody; NT (NPY2R; Neuropeptide Y receptor type 2; NPY-Y2 receptor) (AP); NPY-Y2 receptor; anti-NPY2R antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NPY2R. Species Crossreactivity: mouse
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-NPY2R antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 19-45 in the N-terminal region of human NPY2R.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of mouse bladder tissue lysates (35ug/lane) usingMBS6006275. NPY2R (arrow) was detected using the purified Pab.)

Related Product Information for anti-NPY2R antibody

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

Product Categories/Family for anti-NPY2R antibody

Antibodies; Receptors

References

1. Shoblock, J.R., et al. Psychopharmacology (Berl.) 208(2):265-277(2010). 2. Arnett, D.K., et al. J. Hypertens. 27(8):1585-1593(2009). 3. Zhang, J., et al. Zhonghua Liu Xing Bing Xue Za Zhi 30(7):695-698(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4505447
• NCBI GeneID: 4887
• NCBI Accession #: NP_000901.1
• NCBI GenBank Nucleotide #: NM_000910.2
• UniProt Accession #: P49146; Q13281; Q13457; Q4W5G7; Q6AZZ6; Q9UE67
• Molecular Weight: 42,731 Da
• NCBI Official Full Name: neuropeptide Y receptor type 2
• NCBI Official Synonym Full Names: neuropeptide Y receptor Y2
• NCBI Official Symbol: NPY2R
• NCBI Official Synonym Symbols: NPY2-R
• NCBI Protein Information: neuropeptide Y receptor type 2; Y2 receptor; NPY-Y2 receptor
• UniProt Protein Name: Neuropeptide Y receptor type 2
• Protein Family: Neuropeptide Y receptor
• UniProt Gene Name: NPY2R
• UniProt Synonym Gene Names: NPY2-R; Y2 receptor
• UniProt Entry Name: NPY2R_HUMAN

Uniprot Description

NPY2R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: integral to plasma membrane; nonmotile primary cilium; plasma membrane

Molecular Function: peptide YY receptor activity; protein binding; calcium channel regulator activity; neuropeptide Y receptor activity; receptor activity

Biological Process: positive regulation of dopamine secretion; secretion; positive regulation of cell adhesion; behavioral fear response; negative regulation of synaptic transmission, glutamatergic; positive regulation of peptide secretion; locomotory behavior; negative regulation of cAMP biosynthetic process; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; negative regulation of secretion; positive regulation of smooth muscle contraction; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of sensory perception of pain; positive regulation of circadian sleep/wake cycle, non-REM sleep; nitric oxide mediated signal transduction; negative regulation of neurological process