Rabbit anti-Human Neuroligin 1 Polyclonal Antibody | anti-NLGN1 antibody

Neuroligin 1 (NLGN1)

Cat. Num. AAA618878

• Gene Names: NLGN1; NL1; KIAA1070; MGC45115
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Neuroligin 1; Polyclonal Antibody; Neuroligin 1 (NLGN1); Anti -Neuroligin 1 (NLGN1); anti-NLGN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Neuroligin 1.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, 0.05% sodium azide.

• Applicable Applications for anti-NLGN1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:100,000 using 50-100ng of N1260-01A control peptide/well; Western Blot: 1-10ug/ml using ECL.
• Immunogen: Synthetic peptide corresponding to 17aa of the C-terminus of human NLGN1 (KLH). Species sequence homology: mouse and rat.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-NLGN1 antibody

Neuroligin 1 is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. In addition, the neuroligin/beta-neurexin junction may be involved in the excitatory/inhibitory specification of CNS neuron synapses. A role for Neuroligin 1 is also suggested in autism.

Product Categories/Family for anti-NLGN1 antibody

Antibodies; Abs to Neuroligins

NCBI and Uniprot Product Information

• NCBI GI #: 283139323
• NCBI GeneID: 22871
• UniProt Accession #: Q8N2Q7; Q9UPT2
• Molecular Weight: 93,835 Da
• NCBI Official Full Name: neuroligin 1
• NCBI Official Synonym Full Names: neuroligin 1
• NCBI Official Symbol: NLGN1
• NCBI Official Synonym Symbols: NL1; KIAA1070; MGC45115
• NCBI Protein Information: neuroligin-1; OTTHUMP00000211275; OTTHUMP00000211276
• UniProt Protein Name: Neuroligin-1
• Protein Family: Neuroligin
• UniProt Gene Name: NLGN1
• UniProt Synonym Gene Names: KIAA1070
• UniProt Entry Name: NLGN1_HUMAN

NCBI Description

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq]

Uniprot Description

NLGN1: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q26.31

Cellular Component: filopodium tip; extracellular space; postsynaptic membrane; cell surface; integral to plasma membrane; dendrite; excitatory synapse; synapse; cell junction; N-methyl-D-aspartate selective glutamate receptor complex; external side of plasma membrane

Molecular Function: protein dimerization activity; neurexin binding; cell adhesion molecule binding; receptor activity; PDZ domain binding

Biological Process: positive regulation of filopodium formation; regulation of synaptic transmission; nervous system development; regulation of neuron differentiation; metabolic process; rhythmic process; positive regulation of synaptic transmission, GABAergic; neurological control of breathing; positive regulation of synaptic transmission, glutamatergic; heterophilic cell adhesion; positive regulation of synaptogenesis; establishment of protein localization; synaptogenesis; cytoskeletal matrix organization at active zone; calcium-dependent cell-cell adhesion; protein heterotetramerization; neuron adhesion; synaptic vesicle targeting; protein homooligomerization; protein targeting