Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Rat Neuregulin 1 (NRG1) Polyclonal Antibody | anti-NRG1 antibody
Polyclonal Antibody to Neuregulin 1 (NRG1)
MGHHHHHHSGSEF-GKKKDRGS RGKPGPAEGD PSPALPPRLK EMKSQESAAG SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPENIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN DSASANITIV ESNEFITGMP ASTETAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLI KCAEKEKTFC VNGGECFTVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KAEELYQKRV LTITGICIAL LVVGIMCVV
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded lung tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded lung tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Small intestine Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Small intestine Tissue))
NCBI and Uniprot Product Information
NCBI Description
ligand for Erbb3 and Erbb4 receptors; gene produces many different alternative splicing isoforms; involved in neural and organ development [RGD, Feb 2006]
Uniprot Description
NRG1: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. The cytoplasmic domain interacts with the LIM domain region of LIMK1. Interacts with ERBB3 and ERBB4. Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific. Belongs to the neuregulin family. 10 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Cytokine; Ligand, receptor tyrosine kinase; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q12.3
Cellular Component: apical plasma membrane; axolemma; axon; cytoplasm; dendrite; external side of plasma membrane; extracellular region; extracellular space; integral component of membrane; integral component of plasma membrane; intracellular; neuromuscular junction; nucleoplasm; nucleus; plasma membrane; synapse
Molecular Function: chemorepellent activity; ErbB-2 class receptor binding; ErbB-3 class receptor binding; growth factor activity; integrin binding; protein tyrosine kinase activator activity; receptor binding; receptor tyrosine kinase binding; transcription cofactor activity
Biological Process: activation of MAPK activity; activation of protein kinase B activity; activation of transmembrane receptor protein tyrosine kinase activity; animal organ development; axon ensheathment; brain development; cardiac muscle cell differentiation; cardiac muscle tissue development; cell migration; cell morphogenesis; cell proliferation; cellular protein complex disassembly; chemorepulsion involved in interneuron migration from the subpallium to the cortex; glial cell differentiation; glial cell fate commitment; heart development; locomotory behavior; MAPK cascade; memory; muscle organ development; negative regulation of protein catabolic process; negative regulation of secretion; negative regulation of transcription, DNA-dependent; nervous system development; neurogenesis; neuron fate commitment; neurotransmitter receptor metabolic process; oligodendrocyte differentiation; peripheral nervous system development; positive regulation of axon extension; positive regulation of axon regeneration; positive regulation of cardiac muscle cell proliferation; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of myelination; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of Ras protein signal transduction; positive regulation of striated muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell differentiation; regulation of protein heterodimerization activity; response to progesterone; startle response; synaptogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; ventricular cardiac muscle cell differentiation; wound healing
Research Articles on NRG1
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Product Notes
The NRG1 nrg1 (Catalog #AAA2006763) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Neuregulin 1 (NRG1) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Neuregulin 1 (NRG1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the NRG1 nrg1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF-GKKKDR GS RGKPGPAEGD PSPALPPRLK EMKSQESAAG SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPENIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN DSASANITIV ESNEFITGMP ASTETAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLI KCAEKEKTFC VNGGECFTVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KAEELYQKRV LTITGICIAL LVVGIMCVV. It is sometimes possible for the material contained within the vial of "Neuregulin 1 (NRG1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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