Rabbit anti-Human NEGR1 Polyclonal Antibody | anti-NEGR1 antibody

NEGR1, ID (NEGR1, IGLON4, Neuronal growth regulator 1, IgLON family member 4) (AP)

Cat. Num. AAA6324529

• Gene Names: NEGR1; Ntra; KILON; IGLON4; DMML2433
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: NEGR1; Polyclonal Antibody; ID (NEGR1; IGLON4; Neuronal growth regulator 1; IgLON family member 4) (AP); IgLON family member 4; anti-NEGR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NEGR1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-NEGR1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 189-218 in the central region of human NEGR1, UniProt Accession #NP_776169.2; Q7Z3B1.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in SK-BR-3 cell line lysates (35ug/lane) usingMBS6010696. This demonstrates the NEGR1 antibody detected the NEGR1 protein (arrow).)

Related Product Information for anti-NEGR1 antibody

NEGR1 may be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).

Product Categories/Family for anti-NEGR1 antibody

Antibodies; Neuroscience

References

1. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253 (2010). 2. Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162 (2010). 3. Holzapfel, C., et al. Int J Obes (Lond) 34(10):1538-1545 (2010). 4. Melen, E., et al. J. Allergy Clin. Immunol. 126(3):631-637 (2010). 5. Elks, C.E., et al. PLoS Med. 7 (5), E1000284 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 66346706
• NCBI GeneID: 257194
• NCBI Accession #: NP_776169.2
• NCBI GenBank Nucleotide #: NM_173808.2
• UniProt Accession #: Q7Z3B1; Q5VT21; Q6UY06; Q8NAQ3
• Molecular Weight: 38,719 Da
• NCBI Official Full Name: neuronal growth regulator 1
• NCBI Official Synonym Full Names: neuronal growth regulator 1
• NCBI Official Symbol: NEGR1
• NCBI Official Synonym Symbols: Ntra; KILON; IGLON4; DMML2433
• NCBI Protein Information: neuronal growth regulator 1; neurotractin; a kindred of IgLON; IgLON family member 4
• UniProt Protein Name: Neuronal growth regulator 1
• Protein Family: Neuronal growth regulator
• UniProt Gene Name: NEGR1
• UniProt Synonym Gene Names: IGLON4
• UniProt Entry Name: NEGR1_HUMAN

Uniprot Description

NEGR1: May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain. Belongs to the immunoglobulin superfamily. IgLON family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 1p31.1

Cellular Component: neuron projection; cell surface; cell soma; plasma membrane; intercellular junction

Molecular Function: protein binding

Biological Process: cell-cell adhesion; regulation of neurogenesis; feeding behavior; locomotory behavior