Rabbit anti-Human NEGR1 Polyclonal Antibody | anti-NEGR1 antibody

NEGR1, ID (NEGR1, IGLON4, Neuronal growth regulator 1, IgLON family member 4) (MaxLight 550)

Cat. Num. AAA6324536

• Gene Names: NEGR1; Ntra; KILON; IGLON4; DMML2433
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: NEGR1; Polyclonal Antibody; ID (NEGR1; IGLON4; Neuronal growth regulator 1; IgLON family member 4) (MaxLight 550); IgLON family member 4; anti-NEGR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NEGR1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

• Applicable Applications for anti-NEGR1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 189-218 in the central region of human NEGR1, UniProt Accession #NP_776169.2; Q7Z3B1.
• Conjugate: MaxLight550
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in SK-BR-3 cell line lysates (35ug/lane) usingMBS6010696. This demonstrates the NEGR1 antibody detected the NEGR1 protein (arrow).)

Related Product Information for anti-NEGR1 antibody

NEGR1 may be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).

Product Categories/Family for anti-NEGR1 antibody

Antibodies; Neuroscience

References

1. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253 (2010). 2. Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162 (2010). 3. Holzapfel, C., et al. Int J Obes (Lond) 34(10):1538-1545 (2010). 4. Melen, E., et al. J. Allergy Clin. Immunol. 126(3):631-637 (2010). 5. Elks, C.E., et al. PLoS Med. 7 (5), E1000284 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 66346706
• NCBI GeneID: 257194
• NCBI Accession #: NP_776169.2
• NCBI GenBank Nucleotide #: NM_173808.2
• UniProt Accession #: Q7Z3B1; Q5VT21; Q6UY06; Q8NAQ3
• Molecular Weight: 38,719 Da
• NCBI Official Full Name: neuronal growth regulator 1
• NCBI Official Synonym Full Names: neuronal growth regulator 1
• NCBI Official Symbol: NEGR1
• NCBI Official Synonym Symbols: Ntra; KILON; IGLON4; DMML2433
• NCBI Protein Information: neuronal growth regulator 1; neurotractin; a kindred of IgLON; IgLON family member 4
• UniProt Protein Name: Neuronal growth regulator 1
• Protein Family: Neuronal growth regulator
• UniProt Gene Name: NEGR1
• UniProt Synonym Gene Names: IGLON4
• UniProt Entry Name: NEGR1_HUMAN

Uniprot Description

NEGR1: May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain. Belongs to the immunoglobulin superfamily. IgLON family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 1p31.1

Cellular Component: neuron projection; cell surface; cell soma; plasma membrane; intercellular junction

Molecular Function: protein binding

Biological Process: cell-cell adhesion; regulation of neurogenesis; feeding behavior; locomotory behavior