Rabbit NCAPH2 Polyclonal Antibody | anti-NCAPH2 antibody
NCAPH2 Antibody
Gene Names
NCAPH2; CAPH2
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
NCAPH2; Polyclonal Antibody; NCAPH2 Antibody; CAP H2; CAP H2 subunit of the condensin II complex; CAPH2; Chromosome associated protein H2; Chromosome-associated protein H2; CNDH2_HUMAN; Condensin-2 complex subunit H2; hCAP H2; hCAP-H2; Kleisin beta; Kleisin-beta; Ncaph2; Non SMC condensin II complex subunit H2; Non-SMC condensin II complex subunit H2; anti-NCAPH2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
NCAPH2 Antibody detects endogenous levels of NCAPH2.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-NCAPH2 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human NCAPH2.
Conjugation
Unconjugated
Similarity
Belongs to the CND2 H2 (condensin-2 subunit 2) family.
Subunit Structure
Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits, NCAPG2, NCAPH2 and NCAPD3 that probably regulate the complex.
Function
Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development.
Note
Distributed along the arms of chromosomes assembled in vivo and in vitro.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-NCAPH2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
68,227 Da
NCBI Official Full Name
condensin-2 complex subunit H2 isoform 3
NCBI Official Synonym Full Names
non-SMC condensin II complex, subunit H2
NCBI Official Symbol
NCAPH2
NCBI Official Synonym Symbols
CAPH2
NCBI Protein Information
condensin-2 complex subunit H2; kleisin beta; chromosome-associated protein H2; CAP-H2 subunit of the condensin II complex
UniProt Protein Name
Condensin-2 complex subunit H2
UniProt Gene Name
NCAPH2
UniProt Synonym Gene Names
CAPH2; hCAP-H2
UniProt Entry Name
CNDH2_HUMAN
NCBI Description
This gene encodes one of the non-SMC subunits of the condensin II complex. This complex plays an essential role in mitotic chromosome assembly. Alternate splicing of this gene results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Description
NCAPH2: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture. May play a role in lineage-specific role in T-cell development. Belongs to the CND2 H2 (condensin-2 subunit 2) family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Endoplasmic reticulum; Cell cycle regulation
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: nucleoplasm; membrane; chromosome
Molecular Function: protein binding
Biological Process: chromosome condensation; mitotic cell cycle
Research Articles on NCAPH2
Similar Products
Product Notes
The NCAPH2 ncaph2 (Catalog #AAA9630068) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NCAPH2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NCAPH2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the NCAPH2 ncaph2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NCAPH2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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