Rabbit anti-Human, Mouse NBEA Polyclonal Antibody | anti-NBEA antibody

NBEA Antibody

Cat. Num. AAA9404403

• Gene Names: NBEA; BCL8B; LYST2
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: NBEA; Polyclonal Antibody; NBEA Antibody; BCL8B; LYST2; anti-NBEA antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total NBEA protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1.7 mg/ml (varies by lot)
• Sequence Length: 739

• Applicable Applications for anti-NBEA antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human neurobeachin
• Target Name: NBEA
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/60.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue using at dilution 1/60.)

Related Product Information for anti-NBEA antibody

This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.

Product Categories/Family for anti-NBEA antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 323510703
• NCBI GeneID: 26960
• NCBI Accession #: NP_001191126.1
• NCBI GenBank Nucleotide #: NM_001204197.1
• UniProt Accession #: Q8NFP9; Q5T320; Q9HCM8; Q9NSU1; Q9NW98; Q9Y6J1; B7Z2H9
• Molecular Weight: 84,001 Da
• NCBI Official Full Name: neurobeachin isoform 2
• NCBI Official Synonym Full Names: neurobeachin
• NCBI Official Symbol: NBEA
• NCBI Official Synonym Symbols: BCL8B; LYST2
• NCBI Protein Information: neurobeachin
• UniProt Protein Name: Neurobeachin
• Protein Family: Neurobeachin
• UniProt Gene Name: NBEA
• UniProt Synonym Gene Names: BCL8B; KIAA1544; LYST2
• UniProt Entry Name: NBEA_HUMAN

NCBI Description

This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]

Uniprot Description

neurobeachin: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Belongs to the WD repeat neurobeachin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 13q13

Cellular Component: extrinsic to membrane; plasma membrane; endomembrane system; trans-Golgi network; cytosol

Molecular Function: phospholipid binding; protein kinase binding

Biological Process: protein localization; endosome transport