Rabbit anti-Human NBC3 Polyclonal Antibody | anti-Slc4a7 antibody

NBC3 (HCO3 Cotransporters 3)

Cat. Num. AAA615044

• Gene Names: Slc4a7; NBC3; NBCn1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Serum; Serum
• Synonyms: NBC3; Polyclonal Antibody; NBC3 (HCO3 Cotransporters 3); Anti -NBC3 (HCO3 Cotransporters 3); anti-Slc4a7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NBC3 (HCO3 Cotransporters 3). Species sequence homology: chimp,100%,; rat, 83%; Xenopus, 68%.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.

• Applicable Applications for anti-Slc4a7 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:10,000-1:100,000. Using 50-100ng of control peptide/well.
• Immunogen: A 19-aa peptide sequence within the C-terminus, cytoplasmic domain of human NBC3.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-Slc4a7 antibody

Bicarbonate, along with CO2, is the major pH buffer of biological fluids. The inter-conversion of CO2 to HCO3- is mediated by family of carbonic anhydrases. Several organs specialize in the mobilization of HCO3-. The pancreatic ducts move CO2 and HCO3- from the blood into pancreatic secretions. The kidneys reabsorb massive amount of HCO3- daily (amount of NaHCO3 contained in 1 Ib of baking soda) through the glomerular flirtation of ~180 liters of plasma. To prevent a massive acidosis, thebe tissue specific. Physiologically, NBC is electrogenic, Na+ and HCO3- dependent, Cl- independent, and inhibited by stilbenes (DIDS and SITS). The NBC family of proteins are 30-35% related to anion exchangers (AE2 and AE3; SLC4A1-SLC4A3) and display the same protein topology: (a) At least 10 TM domains with both the N and C-termini predicted to be intracellular, (b) presence of a large, glycosylated, extracellular loop between TM5 and TM6; and (c) the lysine residues are conserved at predicted DIDS-reactive sites.

Product Categories/Family for anti-Slc4a7 antibody

Antibodies; Abs to Ion Transport

NCBI and Uniprot Product Information

• NCBI GI #: 5702100
• NCBI GeneID: 117955
• UniProt Accession #: Q9R1N3; Q9QYD5; Q9R1L1
• Molecular Weight: 135,954 Da
• NCBI Official Full Name: NBC-like protein 3
• NCBI Official Synonym Full Names: solute carrier family 4, sodium bicarbonate cotransporter, member 7
• NCBI Official Symbol: Slc4a7
• NCBI Official Synonym Symbols: NBC3; NBCn1
• NCBI Protein Information: sodium bicarbonate cotransporter 3; NBC-like protein; solute carrier family 4 member 7; electroneutral sodium bicarbonate cotransporter 1
• UniProt Protein Name: Sodium bicarbonate cotransporter 3
• Protein Family: Sodium bicarbonate cotransporter
• UniProt Gene Name: Slc4a7
• UniProt Synonym Gene Names: Nbc; Nbc2; Nbc3; Nbcn1
• UniProt Entry Name: S4A7_RAT

NCBI Description

regulates intracellular pH in different cells along with Na+-driven HCO3- transporters, the Na+-driven Cl-/HCO3- exchanger [RGD]

Uniprot Description

SLC4A7: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. Belongs to the anion exchanger (TC 2.A.31) family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter

Cellular Component: stereocilium; integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; synapse; cytoplasmic vesicle

Molecular Function: inorganic anion exchanger activity; sodium:bicarbonate symporter activity

Biological Process: cochlear nucleus development; visual perception; bicarbonate transport; regulation of intracellular pH; auditory receptor cell development; retinal cell programmed cell death