Structure
Bindarit, Inhibitor
Bindarit
Purity
98.71%
Synonyms
Bindarit; inhibitor
Purity/Purification
98.71%
Molecular Formula
C19H20N2O3
Solubility
DMSO: 65 mg/mL (200.38 mM)
Ethanol: 25 mg/mL (77.1 mM)
Water: <1 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
Ethanol: 25 mg/mL (77.1 mM)
Water: <1 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
Preparation and Storage
Store at -80°C.
Structure
Structure
Related Product Information for Bindarit, inhibitor
Bindarit treatment causes a dose-dependent inhibition of the capacity of human monocytes to produce monocyte chemotactic protein-1 (MCP-1) in response to bacterial LPS or C. albicans with IC50 of 172 uM and 403 uM, respectively. The inhibition of LP-induced MCP-1 production by Bindarit is associated with reduced levels of MCP-1 mRNA transcripts with IC50 of 75 ?M.Bindarit inhibits the production of MCP-1 by LPS-stimulated MM6 cells with IC50 of 425 uM, without affecting the release of IL-8 or IL-6. [2] Bindarit treatment inhibits the release of MCP-1 from IL-1 stimulated osteoblast cell line Saos-2. [3] Bindarit, even atthe maximal concentration, does not exhibit a direct in vitro cytotoxic effect on human IIB-MEL-J melanoma or ECs, although itinhibits MCP-1 expression. [4] Bindarit (10-300 uM) reduces rat vascular smooth muscle cell (VSMC) proliferation, migration,and invasion. [5] Bindarit induces the down regulation of the classical NF-kB pathway. Bindarit displays a specific inhibitory effecton the p65 and p65/p50 induced MCP-1 promoter activation, with no effect on other tested activated promoters, indicating that Bindarit acts on a specific subpopulation of NF-kB isoforms and selects its targets within the whole NF-kB inflammatorypathway. [6] Bindarit modulates cancer-cell proliferation and migration, mainly through negative regulation of TGF-Beta and AKT signaling. [7]
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Product Notes
The Bindarit (Catalog #AAA578958) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Bindarit, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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