Rabbit NARF Polyclonal Antibody | anti-NARF antibody

NARF Polyclonal Antibody

Cat. Num. AAA2560602

• Gene Names: NARF; IOP2
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: NARF; Polyclonal Antibody; NARF Polyclonal Antibody; DKFZp434G0420; FLJ10067; GC17P078009; IOP2; Iron only hydrogenase like protein 2; Nuclear prelamin A recognition factor; Prenyl dependent prelamin A binding protein; anti-NARF antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 1.56mg/mL (varies by lot)
• Sequence Length: 397

• Applicable Applications for anti-NARF antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:300; ELISA: 1:5000-1:10000
• Immunogen: Fusion protein of human NARF
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using NARF Polyclonal Antibody at dilution of 1:45(×200))

Related Product Information for anti-NARF antibody

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. 

Product Categories/Family for anti-NARF antibody

Epigenetics and Nuclear Signaling; Neuroscience; Signal transduction

NCBI and Uniprot Product Information

• NCBI GI #: 84452151
• NCBI GeneID: 26502
• NCBI Accession #: NP_001033707.1; BC016440
• NCBI GenBank Nucleotide #: NP_001033707.1
• UniProt Accession #: Q9UHQ1
• NCBI Official Full Name: nuclear prelamin A recognition factor isoform c
• NCBI Official Synonym Full Names: nuclear prelamin A recognition factor
• NCBI Official Symbol: NARF
• NCBI Official Synonym Symbols: IOP2
• NCBI Protein Information: nuclear prelamin A recognition factor
• UniProt Protein Name: Nuclear prelamin A recognition factor
• Protein Family: Nuclear prelamin A recognition factor
• UniProt Gene Name: NARF
• UniProt Synonym Gene Names: IOP2
• UniProt Entry Name: NARF_HUMAN

NCBI Description

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]