Rabbit NANOS1 / NOS1 Polyclonal Antibody | anti-NANOS1 antibody

Rabbit Polyclonal to Human NANOS1 / NOS1

Cat. Num. AAA244785

• Gene Names: NANOS1; NOS1; SPGF12
• Reactivity: Chimpanzee, Human
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: NANOS1 / NOS1; Polyclonal Antibody; Rabbit Polyclonal to Human NANOS1 / NOS1; Anti-NANOS1 / NOS1 Antibody (aa50-100) IHC-plus; NANOS1; NOS-1; Nanos homolog 1; Nanos homolog 1 (Drosophila); EC_Rep1a; Human NANOS1; NOS1; anti-NANOS1 antibody

• Host: Rabbit
• Reactivity: Chimpanzee, Human
• Clonality: Polyclonal
• Specificity: Human NANOS1
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.05% BSA, 0.05% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 292

• Applicable Applications for anti-NANOS1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 - 10 ug/ml)
• Target Species: Human
• Immunogen Description: A portion of amino acids 50-100 of NANOS1 was used as the immunogen.
• Immunogen Type: Synthetic peptide
• Immunogen: NANOS1 / NOS1 antibody was raised against a portion of amino acids 50-100 of NANOS1 was used as the immunogen.
• Antigen Modification: aa50-100
• Preparation and Storage: Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.

Immunohistochemistry (IHC)

(Anti-NANOS1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-NANOS1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 40804761
• NCBI GeneID: 340719
• NCBI Accession #: NP_955631.1
• NCBI GenBank Nucleotide #: NM_199461.2
• UniProt Accession #: Q8WY41
• Molecular Weight: 30,230 Da
• NCBI Official Full Name: nanos homolog 1
• NCBI Official Synonym Full Names: nanos homolog 1 (Drosophila)
• NCBI Official Symbol: NANOS1
• NCBI Official Synonym Symbols: NOS1; SPGF12
• NCBI Protein Information: nanos homolog 1; NOS-1; EC_Rep1a
• UniProt Protein Name: Nanos homolog 1
• Protein Family: Nanos
• UniProt Gene Name: NANOS1
• UniProt Synonym Gene Names: NOS1; NOS-1
• UniProt Entry Name: NANO1_HUMAN

NCBI Description

This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]

Uniprot Description

NANOS1: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. Belongs to the nanos family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 10q26.11

Cellular Component: perinuclear region of cytoplasm; cytoplasm

Molecular Function: protein binding; translation repressor activity; zinc ion binding; RNA binding

Biological Process: cell migration; negative regulation of translation

Disease: Spermatogenic Failure 12