Rabbit NALP2 Polyclonal Antibody | anti-NALP2 antibody

NALP2 Antibody

Cat. Num. AAA9411583

• Gene Names: NLRP2; NBS1; PAN1; NALP2; PYPAF2; CLR19.9
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Immunoaffinity chromatography purified IgG
• Synonyms: NALP2; Polyclonal Antibody; NALP2 Antibody; NACHT domain-; leucine-rich-repeat-; and PYD-containing protein 2; PYRIN-containing APAF1-like protein2; PAN1; PYPAF2; anti-NALP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Immunoaffinity chromatography purified IgG
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 1062

• Applicable Applications for anti-NALP2 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a peptide corresponding to 12 amino acids near the carboxy terminus of human NALP2.
• Target Name: NALP2
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of NALP2 in PC-3 cell lysate with NALP2 antibody at (A) 1 and (B) 2 ug/ml.)

Related Product Information for anti-NALP2 antibody

NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1b-processing activity and is thought to function as a modulator of NF-kB and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.

Product Categories/Family for anti-NALP2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 8923473
• NCBI GeneID: 55655
• NCBI Accession #: NP_060322
• NCBI GenBank Nucleotide #: NM_017852.3
• Molecular Weight: 117,883 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 2
• NCBI Official Symbol: NLRP2
• NCBI Official Synonym Symbols: NBS1; PAN1; NALP2; PYPAF2; CLR19.9
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 2
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 2
• UniProt Gene Name: NLRP2
• UniProt Synonym Gene Names: NALP2; NBS1; PAN1; PYPAF2
• UniProt Entry Name: NALP2_HUMAN

NCBI Description

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

Uniprot Description

NLRP2: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: cytoplasm

Molecular Function: protein binding; Pyrin domain binding; ATP binding

Biological Process: positive regulation of caspase activity; positive regulation of interleukin-1 beta secretion