Rabbit anti-Human NALP12 Polyclonal Antibody | anti-NLRP12 antibody

NALP12, NT (NACHT LRR and PYD Domains-containing Protein 12, CLR19.3, FCAS2, Monarch 1, Monarch-1, NLR Family Pyrin Domain Containing 12, NLRP12, PAN6, PYRIN Containing APAF1-like Protein 7, PYPAF7, Regulated by Nitric Oxide, RNO, RNO2)

Cat. Num. AAA623400

• Gene Names: NLRP12; RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Purified; Purified by ammonium sulfate precipitation.
• Synonyms: NALP12; Polyclonal Antibody; NT (NACHT LRR and PYD Domains-containing Protein 12; CLR19.3; FCAS2; Monarch 1; Monarch-1; NLR Family Pyrin Domain Containing 12; NLRP12; PAN6; PYRIN Containing APAF1-like Protein 7; PYPAF7; Regulated by Nitric Oxide; RNO; RNO2); Anti -NALP12; anti-NLRP12 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NALP12.
• Purity/Purification: Purified; Purified by ammonium sulfate precipitation.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-NLRP12 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:1,000; Immunohistochemistry: 1:10-1:50
• Immunogen: Synthetic peptide selected from the N-terminal region of human NALP12 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-NLRP12 antibody

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes.

Product Categories/Family for anti-NLRP12 antibody

Antibodies; Abs to Inflammasomes

NCBI and Uniprot Product Information

• NCBI GI #: 21955154
• NCBI GeneID: 91662
• NCBI Accession #: NP_653288.1
• NCBI GenBank Nucleotide #: NM_144687.2
• UniProt Accession #: P59046; Q8NEU4; Q9BY26
• Molecular Weight: 120,173 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 12 isoform 2
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 12
• NCBI Official Symbol: NLRP12
• NCBI Official Synonym Symbols: RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 12; monarch 1; monarch-1; OTTHUMP00000067226; OTTHUMP00000067227; OTTHUMP00000067228; OTTHUMP00000067229; regulated by nitric oxide; PYRIN-containing APAF1-like protein 7; NACHT, LRR and PYD containing protein 12; NACHT, leucine rich repeat and PYD containing 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 12
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP12
• UniProt Synonym Gene Names: NALP12; PYPAF7; RNO
• UniProt Entry Name: NAL12_HUMAN

NCBI Description

This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined. [provided by RefSeq]

Uniprot Description

NLRP12: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK. Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2). FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold. Belongs to the NLRP family. 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; caspase activator activity; ATP binding

Biological Process: caspase activation; release of cytoplasmic sequestered NF-kappaB; negative regulation of cytokine secretion; negative regulation of interleukin-6 biosynthetic process; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-1 beta secretion; regulation of caspase activity; signal transduction; negative regulation of signal transduction; negative regulation of Toll signaling pathway; inhibition of NF-kappaB transcription factor; negative regulation of inflammatory response; positive regulation of MHC class I biosynthetic process; negative regulation of protein amino acid autophosphorylation; regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interleukin-1 secretion; regulation of interleukin-18 biosynthetic process; positive regulation of inflammatory response

Disease: Familial Cold Autoinflammatory Syndrome 2