Rabbit anti-Human NAIP Polyclonal Antibody | anti-NAIP antibody

NAIP Antibody

Cat. Num. AAA9407335

• Gene Names: NAIP; BIRC1; NLRB1; psiNAIP
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: NAIP; Polyclonal Antibody; NAIP Antibody; BIRC1; NLRB1; psiNAIP; anti-NAIP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total NAIP protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1.8 mg/ml (varies by lot)
• Sequence Length: 1403

• Applicable Applications for anti-NAIP antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human NLR family, apoptosis inhibitory protein
• Target Name: NAIP
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/30.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/30.)

Related Product Information for anti-NAIP antibody

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1.

Product Categories/Family for anti-NAIP antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 119393878
• NCBI GeneID: 4671
• NCBI Accession #: NP_004527.2
• NCBI GenBank Nucleotide #: NM_004536.2
• UniProt Accession #: Q13075; O75857; Q13730; Q59GI6; Q8TDZ4; Q99796; B9EG72; E9PHD1
• Molecular Weight: 141,329 Da
• NCBI Official Full Name: baculoviral IAP repeat-containing protein 1 isoform 1
• NCBI Official Synonym Full Names: NLR family, apoptosis inhibitory protein
• NCBI Official Symbol: NAIP
• NCBI Official Synonym Symbols: BIRC1; NLRB1; psiNAIP
• NCBI Protein Information: baculoviral IAP repeat-containing protein 1
• UniProt Protein Name: Baculoviral IAP repeat-containing protein 1
• Protein Family: Putative niacin/nicotinamide transporter
• UniProt Gene Name: NAIP
• UniProt Synonym Gene Names: BIRC1
• UniProt Entry Name: BIRC1_HUMAN

NCBI Description

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

BIRC1: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.

Chromosomal Location of Human Ortholog: 5q13.2

Cellular Component: spindle microtubule; basolateral plasma membrane; cytoplasm; nucleus

Molecular Function: protein binding; metal ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; ATP binding

Biological Process: nervous system development; regulation of signal transduction; protein ubiquitination; innate immune response; negative regulation of caspase activity; negative regulation of neuron apoptosis; inflammatory response; negative regulation of apoptosis