Western Blot (WB)
(Western blot analysis of NADE in Human brain cell lysates with NADE antibody at 1 ug/mL in the presence (A) or absence (B) of blocking peptide.)
Rabbit anti-Human, Mouse NADE Polyclonal Antibody | anti-NADE antibody
NADE Antibody
Gene Names
NGFRAP1; Bex; BEX3; NADE; HGR74; DXS6984E
Reactivity
Human, Mouse
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Ion exchange chromatography purified
Synonyms
NADE; Polyclonal Antibody; NADE Antibody; anti-NADE antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Purity/Purification
Ion exchange chromatography purified
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
111
Applicable Applications for anti-NADE antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Immunogen Type
Peptide
Immunogen Description
Raised against a peptide corresponding to 14 amino acids near the middle of human NADE.
Target Name
NADE
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of NADE in Human brain cell lysates with NADE antibody at 1 ug/mL in the presence (A) or absence (B) of blocking peptide.)
Western Blot (WB)
(Western blot analysis of NADE in Human brain cell lysates with NADE antibody at 1 ug/mL in the presence (A) or absence (B) of blocking peptide.)
Immunohistochemistry (IHC)
(Immunohistochemistry of NADE in human brain tissue with NADE antibody at 2 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of NADE in human brain tissue with NADE antibody at 2 ug/mL.)
Related Product Information for anti-NADE antibody
The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR. Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed. Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells, NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage.
Product Categories/Family for anti-NADE antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
11,762 Da
NCBI Official Full Name
protein BEX3 isoform b
NCBI Official Synonym Full Names
nerve growth factor receptor (TNFRSF16) associated protein 1
NCBI Official Symbol
NGFRAP1
NCBI Official Synonym Symbols
Bex; BEX3; NADE; HGR74; DXS6984E
NCBI Protein Information
protein BEX3
UniProt Protein Name
Protein BEX3
Protein Family
UniProt Gene Name
NGFRAP1
UniProt Synonym Gene Names
BEX3; DXS6984E; NADE
UniProt Entry Name
BEX3_HUMAN
Uniprot Description
NGFRAP1: May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. May play an important role in the pathogenesis of neurogenetic diseases. Belongs to the BEX family.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: Xq22.2
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protein binding; metal ion binding; death receptor binding; caspase activator activity
Biological Process: caspase activation; induction of apoptosis via death domain receptors; nerve growth factor receptor signaling pathway; multicellular organismal development; regulation of caspase activity
Research Articles on NADE
Similar Products
Product Notes
The NADE ngfrap1 (Catalog #AAA9402641) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NADE Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's NADE can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the NADE ngfrap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NADE, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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