Rabbit anti-Human MYT1 Polyclonal Antibody | anti-MYT1 antibody

Anti-MYT1 Antibody, Rabbit Polyclonal

Cat. Num. AAA8101447

• Gene Names: MYT1; MTF1; MYTI; NZF2; PLPB1; ZC2HC4A; C20orf36
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: MYT1; Polyclonal Antibody; Anti-MYT1 Antibody; Rabbit Polyclonal; MYT1 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-C20orf36 Antibody; Anti-MTF1 Antibody; Anti-MYTI Antibody; Anti-PLPB1 Antibody; Anti-ZC2HC4A Antibody; anti-MYT1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human MYT1
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-MYT1 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to the center region of the Human MYT1
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human MYT1, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human MYT1 in human brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

Immunohistochemistry (IHC)

(Immunochemical staining of human MYT1 in human colon carcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-MYT1 antibody

MYT1, encoding the myelin transcription factor 1, was reported as the first gene involved in OAVS, within the retinoic acid (RA) pathway. MYT1 overexpression downregulated all RA receptors genes (RARA, RARB, RARG), involved in RA-mediated transcription, whereas no effect was observed on CYP26A1 expression, the major enzyme involved in RA degradation. Oculo-auriculo-vertebral spectrum (OAVS) is a developmental disorder characterized by hemifacial microsomia associated with ear, eyes and vertebrae malformations showing highly variable expressivity.MYT1 is the first gene implicated in OAVS, within the RA signalling pathway. The MYT1 immunoreactivity was frequently nuclear, appearing as dotted or punctate, but in some cases it was localized to the cytoplasm.

NCBI and Uniprot Product Information

• NCBI GI #: 17975763
• NCBI GeneID: 4661
• NCBI Accession #: NP_004526.1
• NCBI GenBank Nucleotide #: NM_004535.2
• UniProt Accession #: Q01538; O94922; Q7Z5W2; Q9UPV2; E1P5H0; F5H7M8
• Molecular Weight: 125,075 Da
• NCBI Official Full Name: myelin transcription factor 1
• NCBI Official Synonym Full Names: myelin transcription factor 1
• NCBI Official Symbol: MYT1
• NCBI Official Synonym Symbols: MTF1; MYTI; NZF2; PLPB1; ZC2HC4A; C20orf36
• NCBI Protein Information: myelin transcription factor 1; myelin transcription factor I; proteolipid protein binding protein; proteolipid protein-binding protein; neural zinc finger transcription factor 2
• UniProt Protein Name: Myelin transcription factor 1
• Protein Family: Myelin transcription factor
• UniProt Gene Name: MYT1
• UniProt Synonym Gene Names: KIAA0835; KIAA1050; MTF1; MYTI; PLPB1; MyT1; MyTI
• UniProt Entry Name: MYT1_HUMAN

NCBI Description

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]

Uniprot Description

PLPB1: Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: zinc ion binding; transcription factor activity

Biological Process: nervous system development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; cell differentiation